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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy.
Guizhi Zhu,Lei Mei,Harshad D. Vishwasrao,Orit Jacobson,Zhantong Wang,Yijing Liu,Bryant C. Yung,Xiao Fu,Albert J. Jin,Gang Niu,Qin Wang,Fuwu Zhang,Hari Shroff,Xiaoyuan Chen +13 more
TL;DR: Self-assembled intertwining DNA-RNA nanocapsules (iDR-NCs) that efficiently delivered synergistic DNA CpG and short hairpin RNA (shRNA) adjuvants, as well as tumor-specific peptide neoantigens into antigen presenting cells (APCs) in lymph nodes for cancer immunotherapy are reported.
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Are quantum dots ready for in vivo imaging in human subjects
TL;DR: New advances in QD technology such as bioluminescence resonance energy transfer, synthesis of smaller size non-Cd based QDs, improved surface coating and conjugation, and multifunctional probes for multimodality imaging, are likely that human applications of QDs will soon be possible in a clinical setting.
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Design and development of molecular imaging probes.
Kai Chen,Xiaoyuan Chen +1 more
TL;DR: This review summarizes the general principles of molecular Imaging probe design and some fundamental strategies of molecular imaging probe development with a number of illustrative examples.
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Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release.
Sheng Wang,Sheng Wang,Guocan Yu,Zhantong Wang,Orit Jacobson,Lisen Lin,Weijing Yang,Hongzhang Deng,Zhimei He,Yuan Liu,Zhi-Yi Chen,Xiaoyuan Chen +11 more
TL;DR: In vivo results indicate that the cascade of ROS generation and anti-tumor drug release can effectively inhibit tumor growth, and this design of nanomedicine with cascade reactions offers a promising strategy to enhance anti-Tumor efficacy.
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How molecular imaging is speeding up antiangiogenic drug development.
TL;DR: The main focus of this review is the recent advances in tumor angiogenesis imaging, and the targets include vascular endothelial growth factor and vascular endothelium growth factor receptor, integrin αvβ3, matrix metalloproteinase, endoglin, and E-selectin.