Xiaoyuan Chen

TL;DR: A novel method to detect enzymatic activity at the single particle level inside and outside cells by DFM is described, which is the first time to monitor the intracellular metabolism and the effect of anticancer drugs on the cell metabolism using copper growth on the AuNP probes.

TL;DR: The hNVs block CD47-SIRPα signaling axis while promoting M2-to-M1 repolarization within tumor microenvironment, significantly preventing both local recurrence and distant metastasis in malignant melanoma models.

TL;DR: A simple lyophilized kit for labeling PRGD2 peptide (18F-AlF-NOTA-PRGD2, denoted as 18F-alfatide) using a fluoride–aluminum complex that significantly simplified the labeling procedure is developed and can be produced with excellent radiochemical yield and purity via a simple, 1-step, lyophile kit.

TL;DR: A decoy nanoparticle is reported against COVID-19 through a powerful two-step neutralization approach: virus neutralization in the first step followed by cytokine neutralizationIn the second step, the nanodecoys efficiently bind and neutralize inflammatory cytokines including interleukin 6 (IL-6) and granulocyte−macrophage colony-stimulating factor (GM-CSF), and significantly suppress immune disorder and lung injury in an acute pneumonia mouse model.

TL;DR: In this paper, the state-of-the-art progress of fluorescent probes for visualizing pathophysiological microenvironments (viscosity, pH, and polarity), since 2016, as well as the future perspectives in this challenging field.