Xiaoyuan Chen

TL;DR: Results demonstrate that tumor-targeted PDT using GO(HPPH)-PEG-HK could effectively ablate primary tumors and destroy residual tumor cells, thereby preventing distant metastasis by activating host antitumor immunity and suppressing tumor relapse by stimulation of immunological memory.

TL;DR: This Account reviews recent progress in assembling amphiphilic plasmonic nanostructures to create a new class of multifunctional hybrid vesicles and applying them towards cancer diagnosis and therapy and demonstrates that strong interparticle coupling greatly enhances the optical properties (scattering, photothermal conversion, and SERS) in plasMonic vesicle.

TL;DR: Results showed that rapid RIP performed immediately after CCA release reduced infarction by 67% measured at 2 days after stroke, suggesting that RIP blocks ischemic injury by modulating protein synthesis and nerve activity.

TL;DR: In vitro and in vivo investigations demonstrate the metallacage-loaded nanoparticles (MNPs) are more active and show low systemic activity while also possessing emissive properties that allow for fluorescence-based imaging.

TL;DR: In vivo results indicate that the all-in-one polymersomal nanoformulation (CCPS/HPPH/DOX) increases mature DCs in tumor-draining lymph nodes and CD8+ T cells in tumor tissues to inhibit primary and distant MC38 tumor growth following a single intravenous injection with a low dose of DOX and HPPH.