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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
Discovery of Small Molecule Integrin αvβ3 Antagonists as Novel Anticancer Agents
Raveendra Dayam,Francesca Aiello,Jinxia Deng,Yun Wu,Antonio Garofalo,Xiaoyuan Chen,Nouri Neamati +6 more
TL;DR: A series of novel alphavbeta3 antagonists utilizing common feature pharmacophore models are discovered and two compounds with nanomolar to subnanomolar binding affinity are discovered that could be conjugated to paclitaxel for selective delivery to alphvbeta3 positive metastatic cancer cells.
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Tumor Hypoxia Imaging
TL;DR: This review article summarizes and discusses the pros and cons of each currently available method for measuring tissue oxygenation and special emphasis was placed on noninvasive imaging hypoxia with emerging new agents and new imaging technologies to detect the molecular events that are relevant to tumor Hypoxia.
Journal ArticleDOI
Production, Modification and Bio-Applications of Magnetic Nanoparticles Gestated by Magnetotactic Bacteria.
Jin Xie,Kai Chen,Xiaoyuan Chen +2 more
TL;DR: The focus is on how to utilize the knowledge gained from fundamental studies to fabricate functional MTB nanoparticles (MTB-NPs) that are capable of tackling real biomedical problems.
Journal ArticleDOI
Glutathione-Responsive Self-Assembled Magnetic Gold Nanowreath for Enhanced Tumor Imaging and Imaging-Guided Photothermal Therapy.
Yijing Liu,Zhen Yang,Xiaolin Huang,Xiaolin Huang,Guocan Yu,Sheng Wang,Zijian Zhou,Zheyu Shen,Zheyu Shen,Wenpei Fan,Yi Liu,Yi Liu,Matthew Davisson,Heather Kalish,Gang Niu,Zhihong Nie,Xiaoyuan Chen +16 more
TL;DR: The synthesis of magnetic gold nanowreaths (AuNWs) is reported by combining wet-chemical synthesis with layer-by-layer self-assembly with GSH responsiveness to glutathione to enhance T1-weighted MRI and photoacoustic imaging of tumor and be used for imaging-guided photothermal therapy.
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Positron emission tomography tracers for imaging angiogenesis
TL;DR: Because the most intensive work is concentrated on the development of radiolabelled RGD peptides for imaging αvβ3 expression, which has successfully made its way from bench to bedside, these developments are especially emphasized.