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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies.
Pol Escudé Martinez de Castilla,Lingjun Tong,Chenyuan Huang,Alexandros Marios Sofias,Giorgia Pastorin,Xiaoyuan Chen,Gert Storm,Raymond M. Schiffelers,Jiong-Wei Wang +8 more
TL;DR: In this paper, extracellular vesicles (EVs) have emerged as an attractive drug delivery system and the authors assess their pre-clinical applications, in the form of a systematic review.
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Engineered mesenchymal stem cells with enhanced tropism and paracrine secretion of cytokines and growth factors to treat traumatic brain injury.
Zhe Wang,Yu Wang,Yu Wang,Zhiyong Wang,J. Silvio Gutkind,Zhongliang Wang,Fu Wang,Jie Lu,Gang Niu,Gaojun Teng,Xiaoyuan Chen +10 more
TL;DR: It is evidenced that the CXC chemokine receptor 4 (CXCR4)‐SDF1α (stromal cell‐derived factor 1α) axis in engineered MSCs serves not only to attract MSC migration to TBI but also to activate Akt kinase signaling pathway in MSCS to promote paracrine secretion of cytokines and growth factors.
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"Three-in-one" Nanohybrids as Synergistic Nanoquenchers to Enhance No-Wash Fluorescence Biosensors for Ratiometric Detection of Cancer Biomarkers.
Xiaolin Huang,Zhimei He,Dan Guo,Yijing Liu,Jibin Song,Bryant C. Yung,Lisen Lin,Guocan Yu,Jun-Jie Zhu,Yonghua Xiong,Xiaoyuan Chen +10 more
TL;DR: The designed MOF@AuNP@GO-based fluorescence biosensor can serve as a promising platform for washing-free, rapid and sensitive measurement of cancer biomarkers, making this method well-suited for point-of-care (POC) diagnosis.
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Biologically Responsive Plasmonic Assemblies for Second Near-Infrared Window Photoacoustic Imaging-Guided Concurrent Chemo-Immunotherapy.
Rong Zhu,Lichao Su,Jiayong Dai,Zhan-Wei Li,Shumeng Bai,Qingqing Li,Xiaoyuan Chen,Jibin Song,Huanghao Yang +8 more
TL;DR: The BLZ-945 loaded vesicle enabled enhanced PA imaging-guided concurrent chemo-immunotherapy efficacy, inhibiting the growth of both primary tumors and metastatic tumors.
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In situ polymerization on nanoscale metal-organic frameworks for enhanced physiological stability and stimulus-responsive intracellular drug delivery.
Yuan Liu,Christina S. Gong,Yunlu Dai,Zhen Yang,Guocan Yu,Yijing Liu,Mingru Zhang,Lisen Lin,Wei Tang,Zijian Zhou,Guizhi Zhu,Jiji Chen,Orit Jacobson,Dale O. Kiesewetter,Zhantong Wang,Xiaoyuan Chen +15 more
TL;DR: With enhanced stability, cargos loaded into MOF nanoparticles or prodrugs conjugated on the surface can be efficiently delivered and released upon stimulus-responsive cleavage.