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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
Highly robust, recyclable displacement assay for mercuric ions in aqueous solutions and living cells.
Dingbin Liu,Dingbin Liu,Shouju Wang,Magdalena Swierczewska,Xinglu Huang,Xinglu Huang,Ashwinkumar Bhirde,Jiashu Sun,Zhuo Wang,Min Yang,Xingyu Jiang,Xiaoyuan Chen +11 more
TL;DR: A recyclable Hg(2+) probe based on Rhodamine B isothiocyanate (RBITC)-poly(ethylene glycol) (PEG)-comodified gold nanoparticles (AuNPs) with excellent robustness, selectivity, and sensitivity that can be regenerated by resupplying free RBITC into the AuNPs solutions that were already used for detecting HG(2+).
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Quantitative PET imaging of VEGF receptor expression.
TL;DR: The tumor uptake value obtained from PET imaging had good linear correlation with the relative tumor tissue VEGFR-2 expression as measured by Western blot, where r2 equals 0.68 based on the PET uptake at 4 h post-injection.
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PET imaging of acute and chronic inflammation in living mice
TL;DR: PET imaging of TNF-α expression in acute inflammation and integrin αvβ3 expression in chronic inflammation provides the rationale for multiple target evaluation over time to fully understand the inflammation processes.
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Rigid nanoparticle-based delivery of anti-cancer siRNA: Challenges and opportunities
TL;DR: R rigid nanoparticles mostly inorganic nanoparticles and allotropes of carbon nanomaterials, including high surface area, facile surface modification, controllable size, and excellent magnetic/optical/electrical properties, make them promising candidates for targeted siRNA delivery.
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Site-specific PEGylated Exendin-4 modified with a high molecular weight trimeric PEG reduces steric hindrance and increases type 2 antidiabetic therapeutic effects.
Tae Hyung Kim,Hai Hua Jiang,Sung Mook Lim,Yu Seok Youn,Ki Young Choi,Seulki Lee,Xiaoyuan Chen,Youngro Byun,Kang Choon Lee +8 more
TL;DR: The results of this study show that C-terminal specific PEGylation using trimeric PEG is effective when applied to Ex4-Cys and suggest that C40-tPEG(50K)-Ex4- cys has considerable potential as a type 2 antidiabetic agent.