Xiaoyuan Zhang

Bio: Xiaoyuan Zhang is an academic researcher from Beijing University of Chemical Technology. The author has contributed to research in topics: Materials science & Medicine. The author has an hindex of 13, co-authored 35 publications receiving 803 citations. Previous affiliations of Xiaoyuan Zhang include University of Jena.

Fabrication of hollow CuO/PANI hybrid nanofibers for non-enzymatic electrochemical detection of H2O2 and glucose

Abstract: Herein, the hollow CuO/polyaniline (CuO/ PANI) nano-hybrid fibers have been prepared as a novel electrochemical sensor for accurately detecting hydrogen peroxide (H2O2) and glucose. The unique hollow structure of PANI fibers can be achieved by utilizing the polyamic acid (PAA) electrospun fibers as a sacrificial template to promote accessible surface area and reactive sites for sensing. Moreover, in order to enhance the electrochemical properties of PANI fibers, CuO nanoparticles were doped onto the hollow PANI surfaces. Scanning electron microscope (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR) characterizations identify the successful fabrication of hollow CuO/PANI nano-hybrid fibers, which have been designed as a novel non-enzymatic electrochemical biosensor. Furthermore, the H2O2 and glucose sensing tests indicate that the as-prepared non-enzymatic electrochemical biosensor exhibits a wide range, low detection limit, high selectivity, and long-term stability, suggesting the potential application in food security, biomedicine, environmental detection, and pharmaceutical analysis.

One-pot green synthesis, characterizations, and biosensor application of self-assembled reduced graphene oxide–gold nanoparticle hybrid membranes

Abstract: We report here a facile one-pot green synthesis method to prepare a self-assembled membrane of reduced graphene oxide–gold nanoparticle (RGO–AuNP) nanohybrids at a liquid–air interface. The obtained sandwich-like multilayer RGO–AuNP hybrid membranes were characterized by atomic force microscopy, scanning electron microscopy, transmission electron microscopy, UV-vis spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and Raman spectroscopy, and the obtained results prove that GO and chloroauric acid (HAuCl4) were synchronously reduced by glucose successfully. In addition, the experimental data indicate that the self-assembly and formation of RGO–AuNP hybrid membranes are mainly governed by the Brownian motion and electrostatic interaction between RGO and AuNPs, and the encapsulation of AuNPs in the hybrid membrane can be easily adjusted by changing the concentration of HAuCl4. The created functional semi-transparent RGO–AuNP hybrid membranes are very stable in various organic and inorganic solvents, and can be used to fabricate a novel nonenzymatic amperometric biosensor of hydrogen peroxide (H2O2). The fabricated H2O2 biosensor reveals a wide linear range from 0.25 to 22.5 mM, low detection limit of 6.2 μM (S/N = 3), high selectivity, and long-term stability. It is expected that this one-pot green method for fabricating sandwich-like multilayer hybrid functional membranes has broad applications in biosensing, catalysis, and energy storage.

Controlling Protein Adsorption through Nanostructured Polymeric Surfaces.

Abstract: The initial host response to healthcare materials' surfaces after implantation is the adsorption of proteins from blood and interstitial fluids. This adsorbed protein layer modulates the biological/cellular responses to healthcare materials. This stresses the significance of the surface protein assembly for the biocompatibility and functionality of biomaterials and necessitates a profound fundamental understanding of the capability to control protein-surface interactions. This review, therefore, addresses this by systematically analyzing and discussing strategies to control protein adsorption on polymeric healthcare materials through the introduction of specific surface nanostructures. Relevant proteins, healthcare materials' surface properties, clinical applications of polymer healthcare materials, fabrication methods for nanostructured polymer surfaces, amorphous, semicrystalline and block copolymers are considered with a special emphasis on the topographical control of protein adsorption. The review shows that nanostructured polymer surfaces are powerful tools to control the amount, orientation, and order of adsorbed protein layers. It also shows that the understanding of the biological responses to such ordered protein adsorption is still in its infancy, yet it has immense potential for future healthcare materials. The review, which is-as far as it is known-the first one discussing protein adsorption on nanostructured polymer surfaces, concludes with highlighting important current research questions.

The design and biomedical applications of self-assembled two-dimensional organic biomaterials

Abstract: The design and applications of some inorganic two-dimensional (2D) nanomaterials such as graphene, graphyne, and borophene have been widely studied in recent years. Meanwhile, it has been noticed that self-assembling two-dimensional organic biomaterials (2DOBMs) including films, membranes, nanosheets, nanoribbons, grids, arrays, and lattices based on various biomolecules also exhibited promising structures, functions, and applications. The in-depth studies on the self-assembly formation, structural and functional tailoring of 2DOBMs open new avenues for the next generation of novel nanomaterials with adjustable structure and functions, which would further promote the applications of 2DOBMs in materials science, nanodevices, energy and environmental science, biomedicine, tissue engineering, and analytical science. In this review, we summarize important information on the basic principles to fabricate self-assembling 2DOBMs based on peptides, proteins, DNA, RNA, viruses, and other biopolymers. The potential strategies and techniques for tailoring and controlling the structures and functions of 2DOBMs are presented and discussed further. The function-specific biomedical applications of 2DOBMs in biosensors, biomimetic mineralization, cell growth, drug/gene delivery, and bioimaging are also highlighted.

A review on graphene-based nanocomposites for electrochemical and fluorescent biosensors

Abstract: Biosensors with high sensitivity, selectivity and a low limit of detection, reaching nano/picomolar concentrations of biomolecules, are important to the medical sciences and healthcare industry for evaluating physiological and metabolic parameters. Over the last decade, different nanomaterials have been exploited to design highly efficient biosensors for the detection of analyte biomolecules. The discovery of graphene has spectacularly accelerated research on fabricating low-cost electrode materials because of its unique physical properties, including high specific surface area, high carrier mobility, high electrical conductivity, flexibility, and optical transparency. Graphene and its oxygenated derivatives, including graphene oxide (GO) and reduced graphene oxide (rGO), are becoming an important class of nanomaterials in the field of biosensors. The presence of oxygenated functional groups makes GO nanosheets strongly hydrophilic, facilitating chemical functionalization. Graphene, GO and rGO nanosheets can be easily combined with various types of inorganic nanoparticles, including metals, metal oxides, semiconducting nanoparticles, quantum dots, organic polymers and biomolecules, to create a diverse range of graphene-based nanocomposites with enhanced sensitivity for biosensor applications. This review summarizes the advances in two-dimensional (2D) and three-dimensional (3D) graphene-based nanocomposites as emerging electrochemical and fluorescent biosensing platforms for the detection of a wide range of biomolecules with enhanced sensitivity, selectivity and a low limit of detection. The biofunctionalization and nanocomposite formation processes of graphene-based materials and their unique properties, surface functionalization, enzyme immobilization strategies, covalent immobilization, physical adsorption, biointeractions and direct electron transfer (DET) processes are discussed in connection with the design and fabrication of biosensors. The enzymatic and nonenzymatic reactions on graphene-based nanocomposite surfaces for glucose- and cholesterol-related electrochemical biosensors are analyzed. This review covers a very broad range of graphene-based electrochemical and fluorescent biosensors for the detection of glucose, cholesterol, hydrogen peroxide (H2O2), nucleic acids (DNA/RNA), genes, enzymes, cofactors nicotinamide adenine dinucleotide (NADH) and adenosine triphosphate (ATP), dopamine (DA), ascorbic acid (AA), uric acid (UA), cancer biomarkers, pathogenic microorganisms, food toxins, toxic heavy metal ions, mycotoxins, and pesticides. The sensitivity and selectivity of graphene-based electrochemical and fluorescent biosensors are also examined with respect to interfering analytes present in biological systems. Finally, the future outlook for the development of graphene based biosensing technology is outlined.

Functional Graphene Nanomaterials Based Architectures: Biointeractions, Fabrications, and Emerging Biological Applications

Abstract: Functional graphene nanomaterials (FGNs) are fast emerging materials with extremely unique physical and chemical properties and physiological ability to interfere and/or interact with bioorganisms; as a result, FGNs present manifold possibilities for diverse biological applications. Beyond their use in drug/gene delivery, phototherapy, and bioimaging, recent studies have revealed that FGNs can significantly promote interfacial biointeractions, in particular, with proteins, mammalian cells/stem cells, and microbials. FGNs can adsorb and concentrate nutrition factors including proteins from physiological media. This accelerates the formation of extracellular matrix, which eventually promotes cell colonization by providing a more beneficial microenvironment for cell adhesion and growth. Furthermore, FGNs can also interact with cocultured cells by physical or chemical stimulation, which significantly mediate their cellular signaling and biological performance. In this review, we elucidate FGNs–bioorganism int...

MoS2 Nanosheets Vertically Aligned on Carbon Paper: A Freestanding Electrode for Highly Reversible Sodium Ion Batteries

Abstract: The development of sodium-ion batteries for large-scale applications requires the synthesis of electrode materials with high capacity, high initial Coulombic efficiency (ICE), high rate performance, long cycle life, and low cost. A rational design of freestanding anode materials is reported for sodium-ion batteries, consisting of molybdenum disulfide (MoS2) nanosheets aligned vertically on carbon paper derived from paper towel. The hierarchical structure enables sufficient electrode/electrolyte interaction and fast electron transportation. Meanwhile, the unique architecture can minimize the excessive interface between carbon and electrolyte, enabling high ICE. The as-prepared MoS2@carbon paper composites as freestanding electrodes for sodium-ion batteries can liberate the traditional electrode manufacturing procedure, thereby reducing the cost of sodium-ion batteries. The freestanding MoS2@carbon paper electrode exhibits a high reversible capacity, high ICE, good cycling performance, and excellent rate capability. By exploiting in situ Raman spectroscopy, the reversibility of the phase transition from 2H-MoS2 to 1T-MoS2 is observed during the sodium-ion intercalation/deintercalation process. This work is expected to inspire the development of advanced electrode materials for high-performance sodium-ion batteries.

Bacterial Cellulose-Based Composite Scaffolds for Biomedical Applications: A Review

Abstract: Bacterial cellulose (BC), with non-toxicity, high purity, and biocompatibility, has been considered as a versatile candidate for various biomedical applications. Recently, the fabrication of BC-bas...