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Xin Du
Researcher at University of Science and Technology of China
Publications - 50
Citations - 1560
Xin Du is an academic researcher from University of Science and Technology of China. The author has contributed to research in topics: Huntington's disease & Parvalbumin. The author has an hindex of 20, co-authored 47 publications receiving 1256 citations. Previous affiliations of Xin Du include University of Melbourne & Baker IDI Heart and Diabetes Institute.
Papers
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Journal ArticleDOI
Risks of cardiovascular events and effects of routine blood pressure lowering among patients with type 2 diabetes and atrial fibrillation: results of the ADVANCE study.
Xin Du,Toshiharu Ninomiya,Bastiaan E. de Galan,Bastiaan E. de Galan,Edward Abadir,John Chalmers,Avinesh Pillai,Mark Woodward,Mark Woodward,Mark E. Cooper,Stephen B. Harrap,Pavel Hamet,Neil R Poulter,Gregory Y.H. Lip,Anushka Patel +14 more
TL;DR: Atrial fibrillation is relatively common in type 1 diabetes and is associated with substantially increased risks of death and cardiovascular events in patients with type 2 diabetes, and this arrhythmia identifies individuals who are likely to obtain greater absolute benefits from blood pressure-lowering treatment.
Journal ArticleDOI
Altered serotonin receptor expression is associated with depression-related behavior in the R6/1 transgenic mouse model of Huntington's disease
TL;DR: It is shown that pre-motor symptomatic HD mice display sex-specific depressive-related behaviors on the forced-swim, tail-suspension and novelty-suppressed feeding tests while having muted responses to acute anti-depressant administration.
Journal ArticleDOI
Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?
Xin Du,Terence Y. Pang +1 more
TL;DR: The current state of knowledge regarding HPA-axis pathology in Alzheimer’s, PD and HD is summarized, differentiating between prodromal and later stages of disease progression when evidence is available.
Journal ArticleDOI
Sexually dimorphic serotonergic dysfunction in a mouse model of Huntington's disease and depression.
Thibault Renoir,Michelle S. Zajac,Xin Du,Terence Y. Pang,L Leang,Caroline Chevarin,Laurence Lanfumey,Anthony J. Hannan +7 more
TL;DR: This study reveals sex-specific depressive-related behaviors during an early stage of HD prior to any cognitive and motor deficits and suggests a crucial role for disrupted serotonin signaling in mediating the sexually dimorphic depression-like phenotype in HD mice.
Journal ArticleDOI
Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes
Rebecca H. Ritchie,Rebecca H. Ritchie,Jane E Love,Kevin Huynh,Kevin Huynh,Bianca C. Bernardo,Darren C. Henstridge,Helen Kiriazis,Yow Keat Tham,Geeta Sapra,Chengxue Qin,Nelly Cemerlang,Esther J. H. Boey,Karin Jandeleit-Dahm,Xin Du,Xin Du,Julie R. McMullen,Julie R. McMullen +17 more
TL;DR: Results demonstrate that reduced PI3K activity accelerates the development of diabetic cardiomyopathy, and that enhancedPI3K(p110α) activity can prevent adverse cardiac remodelling and dysfunction in a setting of diabetes.