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Xin Hu
Researcher at National Institutes of Health
Publications - 114
Citations - 3575
Xin Hu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Receptor & Chemistry. The author has an hindex of 25, co-authored 104 publications receiving 2365 citations. Previous affiliations of Xin Hu include United States Department of the Army & University of Pennsylvania.
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Journal ArticleDOI
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
Xiaoli Zhang,Xiping Cheng,Lu Yu,Junsheng Yang,Junsheng Yang,Raul Calvo,Samarjit Patnaik,Xin Hu,Qiong Gao,Meimei Yang,Maria Lawas,Markus Delling,Juan J. Marugan,Marc Ferrer,Haoxing Xu +14 more
TL;DR: It is shown that reactive oxygen species (ROS) activate TFEB via a lysosomal Ca2+-dependent mechanism independent of mTOR, which triggers calcineurin-dependent T FEB-nuclear translocation, autophagy induction and lysOSome biogenesis.
Journal ArticleDOI
CERAPP: Collaborative Estrogen Receptor Activity Prediction Project
Kamel Mansouri,Ahmed Abdelaziz,Aleksandra Rybacka,Alessandra Roncaglioni,Alexander Tropsha,Alexandre Varnek,Alexey V. Zakharov,Andrew Worth,Ann M. Richard,Christopher M. Grulke,Daniela Trisciuzzi,Denis Fourches,Dragos Horvath,Emilio Benfenati,Eugene N. Muratov,Eva Bay Wedebye,Francesca Grisoni,Giuseppe Felice Mangiatordi,Giuseppina M. Incisivo,Huixiao Hong,Hui W. Ng,Igor V. Tetko,Ilya A. Balabin,Jayaram Kancherla,Jie Shen,Julien Burton,Marc C. Nicklaus,Matteo Cassotti,Nikolai Georgiev Nikolov,Orazio Nicolotti,Patrik L. Andersson,Qingda Zang,Regina Politi,Richard D. Beger,Roberto Todeschini,Ruili Huang,Sherif Farag,Sine Abildgaard Rosenberg,Svetoslav Slavov,Xin Hu,Richard S. Judson +40 more
TL;DR: This project demonstrated the possibility to screen large libraries of chemicals using a consensus of different in silico approaches and the efficacy of using predictive computational models trained on high-throughput screening data to evaluate thousands of chemicals for ER-related activity and prioritize them for further testing.
Journal ArticleDOI
High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer
Amrita Datta,Hogyoung Kim,Lauren McGee,Adedoyin Johnson,Sudha Talwar,Juan J. Marugan,Noel Southall,Xin Hu,Madhu Lal,Debasis Mondal,Marc Ferrer,Asim B. Abdel-Mageed +11 more
TL;DR: The findings implicate the potential utility of drug-repurposing as novel adjunct therapeutic strategies in advanced cancer.
Journal ArticleDOI
Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses
Jesse M. Jaynes,Rushikesh Sable,Michael Ronzetti,Wendy Bautista,Zachary Knotts,Abisola Abisoye-Ogunniyan,Dandan Li,Raul Calvo,Myagmarjav Dashnyam,Anju Singh,Theresa Guerin,Jason White,Sarangan Ravichandran,Parimal Kumar,Keyur Talsania,Vicky Chen,Anghesom Ghebremedhin,Balasubramanyam Karanam,Ahmad Bin Salam,Ruksana Amin,Taivan Odzorig,Taylor Aiken,Victoria Nguyen,Yansong Bian,Jelani C. Zarif,Amber E. de Groot,Monika Mehta,Lixin Fan,Xin Hu,Anton Simeonov,Nathan Pate,Mones Abu-Asab,Marc Ferrer,Noel Southall,Chan Young Ock,Yongmei Zhao,Henry Lopez,Serguei Kozlov,Natalia de Val,Natalia de Val,Clayton Yates,Bolormaa Baljinnyam,Juan J. Marugan,Udo Rudloff +43 more
TL;DR: RP-182 as mentioned in this paper is a synthetic 10-mer amphipathic analog of host defense peptides that selectively induces a conformational switch of the mannose receptor CD206 expressed on TAMs displaying an M2-like phenotype.
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Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry.
Shu Yang,Miao Xu,Emily M. Lee,Kirill Gorshkov,Sergey A. Shiryaev,Shihua He,Wei Sun,Yu-Shan Cheng,Xin Hu,Anil Mathew Tharappel,Billy Lu,Antonella Pinto,Chen Farhy,Chun-Teng Huang,Zirui Zhang,Wenjun Zhu,Yuying Wu,Yi Zhou,Guang Song,Heng Zhu,Khalida Shamim,Carles Martínez-Romero,Adolfo García-Sastre,Richard A. Preston,Dushyantha Jayaweera,Ruili Huang,Wenwei Huang,Menghang Xia,Anton Simeonov,Guo Li Ming,Xiangguo Qiu,Xiangguo Qiu,Alexey V. Terskikh,Hengli Tang,Hongjun Song,Wei Zheng +35 more
TL;DR: It is shown that emetine, an anti-protozoal agent, potently inhibits ZIKV and EBOV infection with a low nanomolar half maximal inhibitory concentration (IC50) in vitro and potent activity in vivo.