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Xin Xia
Researcher at Sun Yat-sen University
Publications - 7
Citations - 473
Xin Xia is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: AKT3 & Circular RNA. The author has an hindex of 4, co-authored 4 publications receiving 154 citations.
Papers
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Journal ArticleDOI
A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1
Xin Xia,Xixi Li,Fanying Li,Xujia Wu,Maolei Zhang,Huangkai Zhou,Nunu Huang,Xuesong Yang,Feizhe Xiao,Dawei Liu,Lixuan Yang,Nu Zhang +11 more
TL;DR: The data indicate that the impaired circRNA expression of the AKT3 gene contributes to GBM tumorigenesis, and corroborate the hypothesis that restoring AKt3-174aa while inhibiting activated AKT may provide more benefits for certain GBM patients.
Journal ArticleDOI
Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling.
Xinya Gao,Xin Xia,Fanying Li,Maolei Zhang,Huangkai Zhou,Xujia Wu,Jian Zhong,Zheng Zhao,Kun Zhao,Dawei Liu,Feizhe Xiao,Qiang Xu,Tao Jiang,Bo Li,Shi Yuan Cheng,Nu Zhang +15 more
TL;DR: In this paper, an undescribed secretory E-cadherin protein variant (C-E-Cad) encoded by a circular E-cell RNA through multiple-round open reading frame translation was found to activate EGFR in GBM and promote glioma stem cell tumorigenicity.
Journal ArticleDOI
A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity.
Xujia Wu,Songhua Xiao,Maolei Zhang,Lixuan Yang,Jian Zhong,Bo Li,Fanying Li,Xin Xia,Xixi Li,Huangkai Zhou,Dawei Liu,Nunu Huang,Xuesong Yang,Feizhe Xiao,Nu Zhang +14 more
TL;DR: In this article, a novel protein SMO-193a.a. encoded by circular SMO (circ-SMO), which is essential for hedgehog signaling activation in glioblastoma, was described.
Journal ArticleDOI
An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism.
Nunu Huang,Fanying Li,Maolei Zhang,Huangkai Zhou,Zhipeng Chen,Xiao-Yan Ma,Lixuan Yang,Xujia Wu,Jian Zhong,Feizhe Xiao,Xuesong Yang,Kun Zhao,Xixi Li,Xin Xia,Zexian Liu,Song Gao,Nu Zhang +16 more
TL;DR: In this article, the authors describe MP31, a micropeptide encoded by the upstream open reading frame (uORF) of phosphatase and tensin homolog (PTEN) acting as a "circuit breaker" that limits lactate-pyruvate conversion in mitochondria by competing with mLDH for nicotinamide adenine dinucleotide (NAD+).
Journal ArticleDOI
Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression
Xinyuan Lei,Hsinyu Lin,Jie-Hua Wang,Zhanpeng Ou,Yi Jun Ruan,Ananthan Sadagopan,Weixiong Chen,Shule Xie,Baishen Chen,Qunxing Li,Jue Wang,Huayue Lin,Xiaodan Zhu,Xiaoqing Yuan,Tian Tian,Xiao-Bin Lv,Sha Fu,Xiaorui Zhu,Jian Zhou,Guokai Pan,Xin Xia,Bakhos A. Tannous,Soldano Ferrone,Song Fan,Jinsong Li +24 more
TL;DR: In this paper , a mitochondrial fission inhibition with Mdivi-1 upregulates MHC-I expression on cancer cells and enhances the efficacy of adoptive T cell therapy in patient-derived tumor models.