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Xinquan Wang
Researcher at Tsinghua University
Publications - 125
Citations - 14467
Xinquan Wang is an academic researcher from Tsinghua University. The author has contributed to research in topics: Antibody & Medicine. The author has an hindex of 31, co-authored 105 publications receiving 9616 citations. Previous affiliations of Xinquan Wang include Stanford University & Sichuan University.
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Journal ArticleDOI
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor.
Jun Lan,Jiwan Ge,Jinfang Yu,Sisi Shan,Huan Zhou,Shilong Fan,Qi Zhang,Xuanling Shi,Qisheng Wang,Linqi Zhang,Xinquan Wang +10 more
TL;DR: High-resolution crystal structures of the receptor-binding domain of the spike protein of SARS-CoV-2 and SARS -CoV in complex with ACE2 provide insights into the binding mode of these coronaviruses and highlight essential ACE2-interacting residues.
Journal ArticleDOI
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
Xiao-Li Ping,Bao-Fa Sun,Lu Wang,Wen Xiao,Xin Yang,Wenjia Wang,Samir Adhikari,Yue Shi,Ying Lv,Yu-Sheng Chen,Xu Zhao,Ang Li,Ying Yang,Ujwal Dahal,Xiao-Min Lou,Xi Liu,Jun Huang,Weiping Yuan,Xiaofan Zhu,Tao Cheng,Yong-Liang Zhao,Xinquan Wang,Jannie M. Rendtlew Danielsen,Feng Liu,Yun-Gui Yang +24 more
TL;DR: In this paper, two new components of the human m6A methyltransferase complex, Wilms' tumor 1-associating protein (WTAP) and methyl transferase like 14 (METTL14), were reported.
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Human neutralizing antibodies elicited by SARS-CoV-2 infection.
Bin Ju,Qi Zhang,Jiwan Ge,Ruoke Wang,Jing Sun,Xiangyang Ge,Jiazhen Yu,Sisi Shan,Bing Zhou,Shuo Song,Xian Tang,Jinfang Yu,Jun Lan,Jing Yuan,Haiyan Wang,Juanjuan Zhao,Shuye Zhang,Youchun Wang,Xuanling Shi,Lei Liu,Jincun Zhao,Xinquan Wang,Zheng Zhang,Linqi Zhang +23 more
TL;DR: In a study of antibodies isolated from patients infected with SARS-CoV-2, antibodies that potently neutralized the virus competed with angiotensin-converting enzyme 2 for binding to the receptor-binding domain of the viral spike protein, suggesting that antibodies that disrupt this interaction could be developed to treat Sars-Cov-2 infection.
Journal ArticleDOI
Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2
TL;DR: Structural comparisons suggested that the SARS-CoV S glycoprotein retains a prefusion architecture after trypsin cleavage into the S1 and S2 subunits and acidic pH treatment, however, binding to the receptor opens up the receptor-binding domain of S1, which could promote the release of the S 1-ACE2 complex and S1 monomers from the prefusion spike and trigger the pre- to postfusion conformational transition.
Journal ArticleDOI
Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4.
Nianshuang Wang,Xuanling Shi,Liwei Jiang,Senyan Zhang,Dongli Wang,Pei Tong,Dongxing Guo,Lili Fu,Ye Cui,Xi Liu,Kelly C. Arledge,Ying Hua Chen,Linqi Zhang,Xinquan Wang +13 more
TL;DR: The atomic details at the interface between MERS-CoV RBD and DPP4 provide structural understanding of the virus and receptor interaction, which can guide development of therapeutics and vaccines against MERS -CoV infection.