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Xiongjun Wang
Researcher at Chinese Academy of Sciences
Publications - 147
Citations - 3267
Xiongjun Wang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 29, co-authored 136 publications receiving 2430 citations. Previous affiliations of Xiongjun Wang include Laboratory of Molecular Biology & Guangzhou University.
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Journal ArticleDOI
Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2
Ji Liang,Ruixiu Cao,Xiongjun Wang,Yajuan Zhang,Pan Wang,Hong Gao,Chen Li,Fan Yang,Rong Zeng,Ping Wei,Dawei Li,Wenfeng Li,Weiwei Yang +12 more
TL;DR: It is shown that PKM2 translocates to mitochondria under oxidative stress and phosphorylates Bcl2 and inhibits apoptosis directly, highlighting the essential role of PKM 2 in ROS adaptation of cancer cells, and implicate HSP90-PKM2-Bcl2 axis as a potential target for therapeutic intervention in glioblastoma.
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Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis.
Yajuan Zhang,Guanzhen Yu,Huiying Chu,Xiongjun Wang,Lingling Xiong,Guoqing Cai,Ruilong Liu,Hong Gao,Bangbao Tao,Wenfeng Li,Guohui Li,Ji Liang,Weiwei Yang +12 more
TL;DR: A novel mechanism of macrophage-promoted tumor growth by regulating tumor cell metabolism is demonstrated, implicating the therapeutic potential to disrupt the connection between macrophages and tumor cells by inhibiting PGK1 phosphorylation.
Journal ArticleDOI
New diluted ferromagnetic semiconductor with Curie temperature up to 180 K and isostructural to the ‘122’ iron-based superconductors
Kan Zhao,Zhenghao Deng,Xiongjun Wang,W. Han,J. L. Zhu,Xiang Li,Qiufeng Liu,Rencheng Yu,Tatsuo Goko,Benjamin A. Frandsen,Lian Liu,Fanlong Ning,Fanlong Ning,Yasutomo J. Uemura,Hanna Dabkowska,Graeme Luke,Hubertus Luetkens,Elvezio Morenzoni,Sarah Dunsiger,Anatoliy Senyshyn,Peter Böni,Changqing Jin +21 more
TL;DR: The synthesis of a new diluted magnetic semiconductor is reported, which is isostructural to the 122 iron-based superconductors with the tetragonal ThCr( 2)Si(2) (122) structure, which makes them promising for the development of multilayer functional devices.
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Li(Zn,Mn)As as a new generation ferromagnet based on a I–II–V semiconductor
Zhenghao Deng,Changqing Jin,Qiufeng Liu,Xiongjun Wang,J. L. Zhu,S. M. Feng,Leida Chen,Rong Yu,C. Arguello,Tatsuo Goko,Fanlong Ning,Fanlong Ning,Jinsong Zhang,Yayu Wang,Adam A. Aczel,Timothy J. S. Munsie,Travis Williams,Graeme Luke,T. Kakeshita,S. Uchida,Wataru Higemoto,Takashi U. Ito,Bo Gu,Sadamichi Maekawa,Gerald D. Morris,Yasutomo J. Uemura +25 more
TL;DR: This work shows successful synthesis of Li(1+y)(Zn(1-x)Mn(x))As in bulk materials, and theoretically proposed systems based on a I-II-V semiconductor LiZnAs, where isovalent (Zn,Mn) substitution is decoupled from carrier doping with excess/deficient Li concentrations.
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UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis
Xiongjun Wang,Xiongjun Wang,Ruilong Liu,Wencheng Zhu,Huiying Chu,Hua Yu,Ping Wei,Xueyuan Wu,Hongwen Zhu,Hong Gao,Ji Liang,Guohui Li,Weiwei Yang +12 more
TL;DR: It is shown that, after activation of EGFR, UGDH is phosphorylated at tyrosine 473 in human lung cancer cells, and a tumour-suppressive role of UDP-glucose is revealed and a mechanism by which UG DH promotes tumour metastasis by increasing the stability of SNAI1 mRNA is uncovered.