Author
Xiu-Qing Zhang
Bio: Xiu-Qing Zhang is an academic researcher from Shandong University. The author has contributed to research in topics: Atorvastatin & CD80. The author has an hindex of 1, co-authored 1 publications receiving 58 citations.
Topics: Atorvastatin, CD80, FOXP3, Interleukin 17, IL-2 receptor
Papers
More filters
TL;DR: There is strong evidence that atorvastatin can act as an inhibitor in EAN by inhibiting the immune response of Th1 and Th17, decreasing the expression of co-stimulatory molecule, and up-regulating the number of T regulatory cells.
61 citations
Cited by
More filters
TL;DR: A comprehensive review of the literature and analysis of the most outstanding evidence have provided the basis for discussing the most relevant data related to IL-17A blocking agents for the treatment of different disorders, such as psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, cardiovascular disorders and solid cancer.
159 citations
TL;DR: In this paper, a review on the associations between Th17 cells/cytokines and Guillain-Barre syndrome (GBS) and EAN is presented.
109 citations
TL;DR: The experimental evidence pointing out to a potential effect of statins on the role of regulatory T cells in different conditions is reviewed and its potential clinical significance is discussed.
Abstract: Statins are pharmacological inhibitors of the activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), an enzyme responsible for the synthesis of cholesterol. Some recent experimental studies have shown that besides their effects on the primary and secondary prevention of cardiovascular diseases, statins may also have beneficial anti-inflammatory effects through diverse mechanisms. On the other hand, the induction and activity of regulatory T cells (Treg) are key processes in the prevention of pathology during chronic inflammatory and autoimmune diseases. Hence, strategies oriented towards the therapeutic expansion of Tregs are gaining special attention among biomedical researchers. The potential effects of statins on the biology of Treg are of particular importance because of their eventual application as in vivo inducers of Treg in the treatment of multiple conditions. In this paper we review the experimental evidence pointing out to a potential effect of statins on the role of regulatory T cells in different conditions and discuss its potential clinical significance.
72 citations
TL;DR: Recent findings on the activity of statins on Th17 and Treg differentiation and effector function are reviewed and statin-based therapies of multiple sclerosis, a Th17 cell-mediated autoimmune disease, and of Systemic Lupus Erithematosus will be discussed.
71 citations
TL;DR: It is shown that IL-17A neutralization delayed neutrophil accumulation and progression of silica-induced lung inflammation and fibrosis and may mediate the Th immune response to influence silicosis in mice.
66 citations