scispace - formally typeset
Search or ask a question
Author

Xudong Liao

Bio: Xudong Liao is an academic researcher from Nanchang University. The author has contributed to research in topics: Innate immune system & TFAM. The author has an hindex of 1, co-authored 2 publications receiving 3 citations.

Papers
More filters
Journal ArticleDOI
Chengmei Ai1, Xudong Liao1, Yi Zhou1, Zhaohua Yan1, Sen Lin1 
TL;DR: In this paper, a mild and efficient method for deoxygenative C2-sulfonylation of quinoline N-Oxides in the presence of a base has been developed employing extremely inexpensive SO2F2 as an activator and sodium sulfinate as nucleophilic sulfonylation source.

4 citations

Journal ArticleDOI
Xudong Liao1, Yi Zhou1, Chengmei Ai1, Cuijiao Ye1, Guanghui Chen1, Zhaohua Yan1, Sen Lin1 
TL;DR: In this article, a highly efficient and selective oxidation of primary and tertiary amines employing SO2F2/H2O2/base system was described, where primary benzylamines were transformed into nitriles and secondary benzyamines were rearranged to amides.

3 citations

Journal ArticleDOI
TL;DR: In this article , the authors found that NRF1 deficiency resulted in enhanced innate immunity, a diminished viral load, and morbidity in mice, and reported that viruses exploit mitochondrial biogenesis to antagonize innate antiviral immunity.
Abstract: Mitochondrial biogenesis is the process of generating new mitochondria to maintain cellular homeostasis. Here, we report that viruses exploit mitochondrial biogenesis to antagonize innate antiviral immunity. We found that nuclear respiratory factor-1 (NRF1), a vital transcriptional factor involved in nuclear-mitochondrial interactions, is essential for RNA (VSV) or DNA (HSV-1) virus-induced mitochondrial biogenesis. NRF1 deficiency resulted in enhanced innate immunity, a diminished viral load, and morbidity in mice. Mechanistically, the inhibition of NRF1-mediated mitochondrial biogenesis aggravated virus-induced mitochondrial damage, promoted the release of mitochondrial DNA (mtDNA), increased the production of mitochondrial reactive oxygen species (mtROS), and activated the innate immune response. Notably, virus-activated kinase TBK1 phosphorylated NRF1 at Ser318 and thereby triggered the inactivation of the NRF1-TFAM axis during HSV-1 infection. A knock-in (KI) strategy that mimicked TBK1-NRF1 signaling revealed that interrupting the TBK1-NRF1 connection ablated mtDNA release and thereby attenuated the HSV-1-induced innate antiviral response. Our study reveals a previously unidentified antiviral mechanism that utilizes a NRF1-mediated negative feedback loop to modulate mitochondrial biogenesis and antagonize innate immune response.

Cited by
More filters
Journal Article
TL;DR: In this article, an efficient photocatalysts of copper nanoparticles on graphene support are successfully developed for controllably catalyzing the coupling reactions of aromatic nitro compounds to the corresponding azoxy or azo compounds under visible-light irradiation.
Abstract: Copper is a low-cost plasmonic metal. Efficient photocatalysts of copper nanoparticles on graphene support are successfully developed for controllably catalyzing the coupling reactions of aromatic nitro compounds to the corresponding azoxy or azo compounds under visible-light irradiation. The coupling of nitrobenzene produces azoxybenzene with a yield of 90 % at 60 °C, but azobenzene with a yield of 96 % at 90 °C. When irradiated with natural sunlight (mean light intensity of 0.044 W cm−2) at about 35 °C, 70 % of the nitrobenzene is converted and 57 % of the product is azobenzene. The electrons of the copper nanoparticles gain the energy of the incident light through a localized surface plasmon resonance effect and photoexcitation of the bound electrons. The excited energetic electrons at the surface of the copper nanoparticles facilitate the cleavage of the NO bonds in the aromatic nitro compounds. Hence, the catalyzed coupling reaction can proceed under light irradiation and moderate conditions. This study provides a green photocatalytic route for the production of azo compounds and highlights a potential application for graphene.

31 citations

Journal ArticleDOI
TL;DR: In this paper, an efficient and practical approach for the synthesis of sulfonyl quinolines via ball milling promoted coupling of haloquinolines with sulfonic acid under metal-, solvent, and additive-free conditions has been developed.

2 citations

Book ChapterDOI
01 Jan 2021
TL;DR: In this article, the synthesis and derivatization of pyridines, quinolines, and isoquinolines is discussed. But the authors focus on the synthesis of pithy compounds and highlight novel approaches.
Abstract: Pyridines have retained a prominent place in synthetic investigations due in large part to their presence in a number of naturally occurring alkaloids, bioactive agents, and polymeric materials. As such, new synthetic methods continue to be reported aimed at providing facile, atom economical, and environmentally benign access to these ubiquitous targets. This chapter covers the synthesis and derivatization of pyridines, quinolines, and isoquinolines published during 2019, highlighting novel approaches.

1 citations

Journal ArticleDOI
TL;DR: In this article , a deoxygenative C-H functionalization of readily available quinoline-N-oxides with thiourea upon activation with triflic anhydride was presented.
Abstract: Quinoline-2-thiones valuable for synthetic and medicinal chemistry applications were obtained with excellent regioselectivity employing a deoxygenative C-H functionalization of readily available quinoline-N-oxides with thiourea upon activation with triflic anhydride. Unlike the current methods, this approach provides general access to diverse quinoline-2-thiones functionalized with groups of different electronic natures. Experimental simplicity and good to high yields are advantages of this protocol. Given the high reactivity of quinoline-2-thiones, this method provides an entry point for the synthesis of diverse organosulfur quinoline scaffolds.

1 citations

Journal ArticleDOI
TL;DR: In this paper , a mild electrochemical method was developed for the direct C2 sulfonylation of heteroaromatic N-oxides with sulfonyl hydrazides to obtain a serial of 2-sulfonyl quinoline/pyridine derivatives.
Abstract: A mild electrochemical method was developed for the direct C2 sulfonylation of heteroaromatic N-oxides with sulfonyl hydrazides to obtain a serial of 2-sulfonyl quinoline/pyridine derivatives. The method has simple conditions, using potassium carbonate as base, CH3CN/H2O (9 : 1) as solvent, and reacting for 3 h under 15 mA current to prepare expected products.