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Xuehan Zhang
Researcher at University of Toronto
Publications - 2
Citations - 458
Xuehan Zhang is an academic researcher from University of Toronto. The author has contributed to research in topics: Nerve injury & Neuropathic pain. The author has an hindex of 2, co-authored 2 publications receiving 404 citations.
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Journal ArticleDOI
Presynaptic and Postsynaptic Amplifications of Neuropathic Pain in the Anterior Cingulate Cortex
Hui Xu,Long Jun Wu,Hansen Wang,Xuehan Zhang,Kunjumon I. Vadakkan,Susan S. Kim,Hendrik W. Steenland,Min Zhuo +7 more
TL;DR: It is reported that peripheral nerve injury triggered long-term changes in excitatory synaptic transmission in layer II/III neurons within the anterior cingulate cortex (ACC) and that AC1 is critical for such long- term changes.
Journal ArticleDOI
Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain
Hansen Wang,Hui Xu,Long Jun Wu,Susan S. Kim,Tao Chen,Kohei Koga,Giannina Descalzi,Bo Gong,Kunjumon I. Vadakkan,Xuehan Zhang,Bong-Kiun Kaang,Min Zhuo +11 more
TL;DR: The authors screened chemical compounds for inhibition of cyclic AMP production and of the transcription factor CREB in human cells transfected with adenylyl cyclase 1 and identified a lead candidate, NB001, which is relatively selective for AC1 over other adenylate cyclase isoforms.