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Xuekun Li
Researcher at Zhejiang University
Publications - 55
Citations - 6969
Xuekun Li is an academic researcher from Zhejiang University. The author has contributed to research in topics: Neurogenesis & Neural stem cell. The author has an hindex of 26, co-authored 49 publications receiving 6216 citations. Previous affiliations of Xuekun Li include Emory University & Peking Union Medical College.
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Journal ArticleDOI
Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome
Miao Yu,Gary C. Hon,Keith E. Szulwach,Chun-Xiao Song,Liang Zhang,Audrey Kim,Xuekun Li,Qing Dai,Yin Shen,Beomseok Park,Jung Hyun Min,Peng Jin,Bing Ren,Chuan He +13 more
TL;DR: Application of Tet-assisted bisulfite sequencing to embryonic stem cells not only confirms widespread distribution of 5hmC in the mammalian genome but also reveals sequence bias and strand asymmetry at5hmC sites.
Journal ArticleDOI
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
Chun-Xiao Song,Keith E. Szulwach,Ye Fu,Qing Dai,Chengqi Yi,Xuekun Li,Yujing Li,Chih Hsin Chen,Wen Zhang,Xing Jian,Jing Wang,Li Zhang,Timothy J. Looney,Baichen Zhang,Lucy A. Godley,Leslie M. Hicks,Bruce T. Lahn,Peng Jin,Chuan He +18 more
TL;DR: This method uses the T4 bacteriophage β-glucosyltransferase to transfer an engineered glucose moiety containing an azide group onto the hydroxyl group of 5-hmC, a recently identified epigenetic modification present in substantial amounts in certain mammalian cell types.
Journal ArticleDOI
5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging
Keith E. Szulwach,Xuekun Li,Yujing Li,Chun-Xiao Song,Hao Wu,Qing Dai,Hasan A. Irier,Anup K. Upadhyay,Marla Gearing,Allan I. Levey,Aparna Vasanthakumar,Lucy A. Godley,Qiang Chang,Xiaodong Cheng,Chuan He,Peng Jin +15 more
TL;DR: The mapped 5-hmC genome-wide in mouse hippocampus and cerebellum at three different ages allowed us to assess its stability and dynamic regulation during postnatal neurodevelopment through adulthood, and found developmentally programmed acquisition of 5-HMC in neuronal cells.
Journal ArticleDOI
Cross talk between microRNA and epigenetic regulation in adult neurogenesis.
Keith E. Szulwach,Xuekun Li,Richard D. Smrt,Yujing Li,Yuping Luo,Li Lin,Nicholas J. Santistevan,Wendi Li,Xinyu Zhao,Peng Jin +9 more
TL;DR: The microRNA miR-137 represses expression of Ezh2, a histone methyltransferase, which in turn alters the epigenetic architecture of chromatin that is important for regulation of miR -137 levels.
Journal ArticleDOI
MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase Mind Bomb-1
Richard D. Smrt,Keith E. Szulwach,Rebecca L. Pfeiffer,Xuekun Li,Weixiang Guo,Manavendra Pathania,Zhao-Qian Teng,Yuping Luo,Junmin Peng,Angélique Bordey,Peng Jin,Xinyu Zhao +11 more
TL;DR: A novel miRNA‐mediated mechanism involving miR‐137 and Mib1 that function to regulate neuronal maturation and dendritic morphogenesis during development is demonstrated.