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Xueping Chen
Researcher at University of Manitoba
Publications - 6
Citations - 1420
Xueping Chen is an academic researcher from University of Manitoba. The author has contributed to research in topics: Oxidative stress & Mitochondrial respiratory chain. The author has an hindex of 6, co-authored 6 publications receiving 1004 citations. Previous affiliations of Xueping Chen include Sichuan University.
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Journal ArticleDOI
Oxidative stress, mitochondrial damage and neurodegenerative diseases
TL;DR: The contribution of oxidative stress and mitochondrial damage to the onset of neurodegenerative eases is summarized and strategies to modify mitochondrial dysfunction that may be attractive therapeutic interventions for the treatment of various neurodegnerative diseases are discussed.
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Oxidative stress in neurodegenerative diseases.
TL;DR: This review presents as much detailed information as possible that is available on various neurodegenerative disorders and their connection with oxidative stress to present a variety of therapeutic strategies designed to address these pathological processes.
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SOD1 aggregation in astrocytes following ischemia/reperfusion injury: a role of NO-mediated S-nitrosylation of protein disulfide isomerase (PDI)
TL;DR: NO-mediated S-nitrosylation of PDI may be involved in the formation of the SOD1-linked ubiquitinated-protein aggregates in cerebral ischemia/reperfusion injury.
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S-nitrosylated protein disulfide isomerase contributes to mutant SOD1 aggregates in amyotrophic lateral sclerosis.
Xueping Chen,Xiaosha Zhang,Chen Li,Teng Guan,Huifang Shang,Liying Cui,Xin-Min Li,Jiming Kong +7 more
TL;DR: It is concluded that NO‐mediated S‐nitrosylation of PDI is a contributing factor to the accumulation of mutant SOD1 aggregates in amyotrophic lateral sclerosis.
Journal ArticleDOI
Oxidative Modification of Cysteine 111 Promotes Disulfide Bond-Independent Aggregation of SOD1
Xueping Chen,Huifang Shang,Xiaozhong Qiu,Xiaozhong Qiu,Noriko Fujiwara,Liying Cui,Xin-Min Li,Tian-Ming Gao,Jiming Kong,Jiming Kong +9 more
TL;DR: This work systematically examined the redox state of SOD1 cysteine residues in the G37R transgenic mouse model at different stages of the disease and under oxidative stress induced by H2O2, and found that accumulated oxidative stress facilitated the formation of aggregates, which were not mediated by disulfide bond.