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Xueping Qu
Researcher at University of Texas Southwestern Medical Center
Publications - 7
Citations - 7589
Xueping Qu is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Autophagy & Medicine. The author has an hindex of 4, co-authored 4 publications receiving 7021 citations. Previous affiliations of Xueping Qu include Columbia University.
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Journal ArticleDOI
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.
Sophie Pattingre,Sophie Pattingre,Amina T. Tassa,Xueping Qu,Xueping Qu,Rita Garuti,Xiao Huan Liang,Noboru Mizushima,Milton Packer,Michael D. Schneider,Beth Levine,Beth Levine +11 more
TL;DR: Bcl-2 not only functions as an antiapoptotic protein, but also as an antiautophagy protein via its inhibitory interaction with Beclin 1, which may help maintain autophagy at levels that are compatible with cell survival, rather than cell death.
Journal ArticleDOI
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
Xueping Qu,Jie Yu,Govind Bhagat,Norihiko Furuya,Hanina Hibshoosh,Andrea B. Troxel,Jeffrey M. Rosen,Eeva-Liisa Eskelinen,Noboru Mizushima,Yoshinori Ohsumi,Giorgio Cattoretti,Beth Levine +11 more
TL;DR: It is shown that heterozygous disruption of beclin 1 increases the frequency of spontaneous malignancies and accelerates the development of hepatitis B virus-induced premalignant lesions, providing genetic evidence that autophagy is a novel mechanism of cell-growth control and tumor suppression.
Journal ArticleDOI
Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion: Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy
Yutaka Matsui,Hiromitsu Takagi,Xueping Qu,Maha Abdellatif,Hideyuki Sakoda,Tomoichiro Asano,Beth Levine,Junichi Sadoshima,Junichi Sadoshima +8 more
TL;DR: The results suggest that, in the heart, ischemia stimulates autophagy through an AMPK-dependent mechanism, whereas ischemIA/reperfusion stimulates autophile through a Beclin 1–dependent but AM PK-independent mechanism.
Journal ArticleDOI
Autophagy Gene-Dependent Clearance of Apoptotic Cells during Embryonic Development
Xueping Qu,Zhongju Zou,Qihua Sun,Katherine Luby-Phelps,Pengfei Cheng,Robert N Hogan,Christopher J. Gilpin,Beth Levine +7 more
TL;DR: It is concluded that autophagy contributes to dead-cell clearance during PCD by a mechanism that likely involves the generation of energy-dependent engulfment signals.
Journal ArticleDOI
ARID1A mutations confer intrinsic and acquired resistance to cetuximab treatment in colorectal cancer
Radia M. Johnson,Xueping Qu,Chunrun Lin,Ling Huw,Avinashnarayan Venkatanarayan,Ethan Sokol,Fang Shu Ou,Nnamdi Ihuegbu,Oliver A. Zill,Omar Kabbarah,Lisa Wang,Richard Bourgon,Felipe De Sousa E Melo,Christopher R. Bolen,Anneleen Daemen,Alan P. Venook,Federico Innocenti,Heinz-Josef Lenz,Carlos Bais +18 more
TL;DR: In this paper , the authors show that anti-EGFR but not anti-VEGF treatment enriches for emerging ARID1A mutations in colorectal cancer patients and that patients with ARID 1A mutations, at baseline, are associated with worse outcome when treated with cetuximab- but not bevacizumab-containing therapies.