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Xuesi Chen

Other affiliations: Nankai University, Waseda University, Shanghai University  ...read more
Bio: Xuesi Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Drug delivery & Micelle. The author has an hindex of 99, co-authored 979 publications receiving 41685 citations. Previous affiliations of Xuesi Chen include Nankai University & Waseda University.


Papers
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Huayu Tian1, Zhaohui Tang1, Xiuli Zhuang1, Xuesi Chen1, Xiabin Jing1 
TL;DR: This review presents a comprehensive introduction to various types of synthetic biodegradable polymers with reactive groups and bioactive groups, and further describes their structure, preparation procedures and properties.

1,088 citations

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TL;DR: It was shown that the drugs were capsulated inside of the fibers and the drug release in the presence of proteinase K followed nearly zero-order kinetics due to the degradation of the PLLA fibers.

824 citations

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TL;DR: The burst release of the drugs can be avoided by using compatible drugs with polymers, and the drug release can follow nearly zero-order kinetics due to the degradation of the PLLA fibers in the presence of proteinase K.

433 citations

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TL;DR: A comprehensive overview of the recent progress and potential developments of electrospun polymer matrices and their application as biomaterials is presented in this paper, where the authors present a comprehensive overview.

429 citations

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TL;DR: The results of biocompatibility test showed that the g-HAP existing in the PLLA composite facilitated both adhesion and proliferation of chondrocytes on the P LLA/g-H AP composite film, implying that PLLa could be strengthened as well as toughened by g- HAP nano-particles.

412 citations


Cited by
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[...]

08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

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TL;DR: Recent advances in the design of nanoscale stimuli-responsive systems that are able to control drug biodistribution in response to specific stimuli, either exogenous (variations in temperature, magnetic field, ultrasound intensity, light or electric pulses) or endogenous (changes in pH, enzyme concentration or redox gradients).
Abstract: Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible. Implementation of such devices requires the use of biocompatible materials that are susceptible to a specific physical incitement or that, in response to a specific stimulus, undergo a protonation, a hydrolytic cleavage or a (supra)molecular conformational change. In this Review, we discuss recent advances in the design of nanoscale stimuli-responsive systems that are able to control drug biodistribution in response to specific stimuli, either exogenous (variations in temperature, magnetic field, ultrasound intensity, light or electric pulses) or endogenous (changes in pH, enzyme concentration or redox gradients).

4,836 citations

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TL;DR: This review presents an overview of the electrospinning technique with its promising advantages and potential applications, and focuses on varied applications of electrospun fibers in different fields.

3,932 citations