Xufeng S. Wu

TL;DR: A new microscope using ultrathin light sheets derived from two-dimensional optical lattices is developed, demonstrating the performance advantages of lattice light-sheet microscopy compared with previous techniques and highlighted phenomena that, when seen at increased spatiotemporal detail, may hint at previously unknown biological mechanisms.

TL;DR: A map of 30,181 human gene-based markers was assembled and integrated with the current genetic map by radiation hybrid mapping, which contains nearly twice as many genes as the previous release and is twofold to threefold more accurate than the previous version.

TL;DR: The results provide the first molecular description of an organelle receptor for an actin-based motor, illustrate how alternate exon usage can be used to specify cargo, and further expand the functional repertoire of Rab GTPases and their effectors.

TL;DR: Actin and myosin IIA have been implicated in the inward movement of receptor clusters at the immunological synapse of T lymphocytes and their spatial organization is defined and quantified.

TL;DR: Rab GTPases and their effectors regulate membrane traffic by determining the specificity of transport vesicle docking and fusion steps, and several Rabs have been linked to specific microtubule- or actin-based motor proteins.