Xumu Zhang

TL;DR: The increasing demand to produce enantiomerically pure pharmaceuticals, agrochemicals, flavors, and other fine chemicals has advanced the field of asymmetric catalytic technologies, and asymmetric hydrogenation utilizing molecular hydrogen to reduce prochiral olefins, ketones, and imines has become one of the most efficient methods for constructing chiral compounds.

TL;DR: Both the most promising biomimetic and practical catalysts have arisen from systems that can be systematically modified by convenient synthetic methodology.

TL;DR: It is found that high enantioselectivities have been achieved in the [3 + 2] cycloaddition of azomethine ylides and a new bis-ferrocenyl amide phosphine (FAP) as the ligand is used.

TL;DR: The first asymmetric cycloaddition with chiral monophosphines was reported in this article, where the authors used 2,5-dialkyl-7phenyl-7phosphabicyclo[2.2.1]heptanes as catalysts.

TL;DR: This Account outlines the efforts in ligand development for asymmetric hydrogenation, including ligands with phosphocyclic motifs, atropisomeric backbones, and bisphosphine ligands inspired by the structure of 2,3- O-isopropylidene-2, 3-dihydroxyl-1,4-bis(diphenylphosphino)butane (DIOP).