Author
Xun Shen
Other affiliations: Shanghai University
Bio: Xun Shen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Respiratory burst & Protein kinase C. The author has an hindex of 4, co-authored 6 publications receiving 575 citations. Previous affiliations of Xun Shen include Shanghai University.
Papers
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TL;DR: NF-kappaB p65 subunit repressed the Nrf2-antioxidant response element (ARE) pathway at transcriptional level and might provide a new insight into a possible role of NF- kappaB in suppressing the expression of anti-inflammatory or anti-tumor genes.
560 citations
TL;DR: It was found that about two-thirds of the activation of respiratory burst initiated by the receptor agonist were attributed to the Ca2+ influx under normal physiological conditions, and the Ca1+ influx from extracellular space plays an important role either in generation of reactive oxygen metabolites or in activation of protein kinase C.
53 citations
TL;DR: The data provide the first evidence that CD146 dimerization occurs in living cells and is regulated within the tumor microenvironment, implying thatDimerization of CD146 may be associated with malignancy.
32 citations
TL;DR: The study revealed that the fast onset of the fMLP- Stimulated respiratory burst in comparison with PMA-stimulated response is not only due to the transient rise of [Ca2+]i, but is also due toThe higher efficiency of diacylglycerol (DAG) in activating protein kinase c (PKC).
27 citations
TL;DR: The results suggest that N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) primes the fMLP stimulation by direct action on actin leading to breakdown of microfilaments and more expression of formyl peptide receptors, and inhibits the stimulation by indirect action onActin through inactivation of some Ca(2+)-dependent proteins resulting in assembly of actin into micro Filaments.
4 citations
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TL;DR: Saponins are steroid or triterpenoid glycosides, common in a large number of plants and plant products that are important in human and animal nutrition and they have also been found to significantly affect growth, feed intake and reproduction in animals.
Abstract: Saponins are steroid or triterpenoid glycosides, common in a large number of plants and plant products that are important in human and animal nutrition. Several biological effects have been ascribed to saponins. Extensive research has been carried out into the membrane-permeabilising, immunostimulant, hypocholesterolaemic and anticarcinogenic properties of saponins and they have also been found to significantly affect growth, feed intake and reproduction in animals. These structurally diverse compounds have also been observed to kill protozoans and molluscs, to be antioxidants, to impair the digestion of protein and the uptake of vitamins and minerals in the gut, to cause hypoglycaemia, and to act as antifungal and antiviral agents. These compounds can thus affect animals in a host of different ways both positive and negative.
1,544 citations
TL;DR: The members of the Keap1/Nrf2/ARE signal pathway and its downstream genes, the effects of this pathway on animal models of inflammatory diseases, and crosstalk with the NF-κB pathway are discussed.
1,086 citations
TL;DR: During progression and metastasis, tumor cells adapt to oxidative stress by increasing NADPH in various ways, including activation of AMPK, the PPP, and reductive glutamine and folate metabolism.
852 citations
TL;DR: Understanding of how the transcription factor is regulated indicates ways in which drug resistance in tumours could be overcome and Somatic mutations in KEAP1 and NRF2 provide an insight into the molecular mechanisms by whichNRF2 is regulated.
788 citations
TL;DR: This review focuses on the potentially complex molecular mechanisms that link the Nrf2 and NF-κB pathways and the importance of designing more effective therapeutic strategies to prevent or treat a broad range of neurological disorders.
Abstract: In most tissues, cells are exposed to frequent changes in levels of oxidative stress and inflammation. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor-κB (NF-κB) are the two key transcription factors that regulate cellular responses to oxidative stress and inflammation respectively. Pharmacological and genetic studies suggest that there is functional cross-talk between these two important pathways. The absence of Nrf2 can exacerbate NF-κB activity leading to increased cytokine production, whereas NF-κB can modulate Nrf2 transcription and activity, having both positive and negative effects on the target gene expression. This review focuses on the potentially complex molecular mechanisms that link the Nrf2 and NF-κB pathways and the importance of designing more effective therapeutic strategies to prevent or treat a broad range of neurological disorders.
738 citations