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Xun Wu
Researcher at University of Manitoba
Publications - 7
Citations - 245
Xun Wu is an academic researcher from University of Manitoba. The author has contributed to research in topics: Cell migration & B cell. The author has an hindex of 5, co-authored 7 publications receiving 206 citations.
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Journal ArticleDOI
Recent developments in microfluidics-based chemotaxis studies
Jiandong Wu,Xun Wu,Francis Lin +2 more
TL;DR: Recent developments in microfluidic-based chemotaxis studies are reviewed and the new trends in this field observed over the past few years are discussed.
Journal ArticleDOI
Distinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration
Ahmed Y. Ali,Xun Wu,Nour Eissa,Sen Hou,Jean-Eric Ghia,Thomas T. Murooka,Versha Banerji,James B. Johnston,Francis Lin,Spencer B. Gibson,Aaron J. Marshall +10 more
TL;DR: Microscopic tracking of cell migration within chemokine gradients revealed that PI3Kγ functions in gradient sensing and impacts cell morphology and F-actin polarization, providing the first evidence that PI 3Kγ has unique functions in malignant B cells.
Journal ArticleDOI
The tandem PH domain-containing protein 2 (TAPP2) regulates chemokine-induced cytoskeletal reorganization and malignant B cell migration.
TL;DR: TAPP2 function in cell migration is also apparent in the more complex context of B cell migration into stromal cell layers – a process that is only partially dependent on PI3K and SDF-1.
Journal ArticleDOI
Phosphatidylinositol-3,4-Bisphosphate and Its Binding Protein Lamellipodin Regulate Chemotaxis of Malignant B Lymphocytes
Hongzhao Li,Xun Wu,Sen Hou,Mouhannad Malek,Anna Kielkowska,Edward Noh,Kennedy J. Makondo,Qiujiang Du,John A. Wilkins,James B. Johnston,Spencer B. Gibson,Francis Lin,Aaron J. Marshall +12 more
TL;DR: It is found that cells expressing wild-type, but not phosphatase dead, inositol polyphosphate 4-phosphatase show impaired SDF-induced PI(3,4)P2 responses and reduced migration in Transwell chamber assays, and depletion in primary chronic lymphocytic leukemia cells significantly impaired their migration capacity.
Journal ArticleDOI
Altered T Follicular Helper Cell Subsets and Function in Chronic Lymphocytic Leukemia.
Xun Wu,J. Ernesto Fajardo-Despaigne,Christine Y. Zhang,Vishala Neppalli,Versha Banerji,James B. Johnston,Spencer B. Gibson,Aaron J. Marshall +7 more
TL;DR: In this paper, the authors find that TFH cells are elevated in CLL patients and are phenotypically abnormal, expressing higher levels of PD-1, TIGIT, CD40L, IFNγ and IL-21, and exhibiting abnormal composition of TFH1, TFH2 and TFH17 subsets.