Y Boyle

TL;DR: The results suggest that studies of experimental pain provide a relevant but quantitatively incomplete picture of brain activity during arthritic pain, and the search for new analgesics for arthritis that act on the brain should focus on drugs that modify this circuitry.

TL;DR: Sources analysis (LORETA) revealed that uncertainty about expected heat intensity involves an anticipatory cortical network commonly associated with attention, however, relative certainty involves cortical areas previously associated with semantic and prospective memory (left inferior frontal and inferior temporal cortex, and right anterior prefrontal cortex).

TL;DR: This work has used an acute tryptophan depletion to manipulate 5-HT function and examined its effects of ATD on heat pain threshold and tolerance, attentional manipulation of nociceptive processing and mood in human volunteers, and is the first demonstration of 5- HT effects on pain perception which are not confounded by mood changes.

TL;DR: In this article, the effects of noise distraction on the different components and sources of laser-evoked potentials (LEPs) whilst attending to either the spatial component (localisation performance task) or the affective component (unpleasantness rating task) of pain were investigated.

TL;DR: The aim of this experiment was to assess the effect of MRI scanner noise, compared to white noise, on the affective (unpleasantness) and the sensory-discriminative (localisation) components of pain.