Author
Y. Cai
Bio: Y. Cai is an academic researcher from Fudan University. The author has contributed to research in topics: Odds ratio & Suicidal ideation. The author has an hindex of 2, co-authored 2 publications receiving 43 citations.
Papers
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Wellcome Trust Centre for Human Genetics1, Fudan University2, Shanghai Jiao Tong University3, Tongji University4, Jiangsu University5, Zhejiang Chinese Medical University6, Zhengzhou University7, Harbin Medical University8, Sichuan University9, Capital Medical University10, China Medical University (PRC)11, Sun Yat-sen University12, Shanxi Medical University13, Jinan University14, Hebei Medical University15, Lanzhou University16, Fourth Military Medical University17, Virginia Commonwealth University18
TL;DR: The results suggest that cultural factors impact on patterns of parenting and their association with MD, and high parental protectiveness is generally pathogenic in Western countries but protective in China, especially when received from the father.
Abstract: Background. In Western countries, a history of major depression (MD) is associated with reports of received parenting that is low in warmth and caring and high in control and authoritarianism. Does a similar pattern exist in women in China? Method. Received parenting was assessed by a shortened version of the Parental Bonding Instrument (PBI) in two groups of Han Chinese women: 1970 clinically ascertained cases with recurrent MD and 2597 matched controls. MD was assessed at personal interview. Results. Factor analysis of the PBI revealed three factors for both mothers and fathers : warmth, protectiveness, and authoritarianism. Lower warmth and protectiveness and higher authoritarianism from both mother and father were significantly associated with risk for recurrent MD. Parental warmth was positively correlated with parental protectiveness and negatively correlated with parental authoritarianism. When examined together, paternal warmth was more strongly associated with lowered risk for MD than maternal warmth. Furthermore, paternal protectiveness was negatively and maternal protectiveness positively associated with risk for MD. Conclusions. Although the structure of received parenting is very similar in China and Western countries, the association with MD is not. High parental protectiveness is generally pathogenic in Western countries but protective in China, especially when received from the father. Our results suggest that cultural factors impact on patterns of parenting and their association with MD.
37 citations
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China Medical University (PRC)1, Zhejiang Chinese Medical University2, Zhengzhou University3, Capital Medical University4, Shanxi Medical University5, Sun Yat-sen University6, Jiangsu University7, Harbin Medical University8, Hebei Medical University9, Lanzhou University10, Chongqing Medical University11, Sichuan University12, Tongji University13, Shanghai Jiao Tong University14, Fudan University15, Jinan University16, Fourth Military Medical University17, Wellcome Trust Centre for Human Genetics18, Clinical Trial Service Unit19, Virginia Commonwealth University20
TL;DR: Identifying specific depressive symptoms and co-morbid psychiatric disorders may help improve the clinical assessment of suicide risk in depressed patients and could be helpful in identifying those who need more intense treatment strategies in order to prevent suicide.
Abstract: BackgroundThe relationship between recurrent major depression (MD) in women and suicidality is complex. We investigated the extent to which patients who suffered with various forms of suicidal symptomatology can be distinguished from those subjects without such symptoms.MethodWe examined the clinical features of the worst episode in 1970 Han Chinese women with recurrent DSM-IV MD between the ages of 30 and 60 years from across China. Student's t tests, and logistic and multiple logistic regression models were used to determine the association between suicidality and other clinical features of MD.ResultsSuicidal symptomatology is significantly associated with a more severe form of MD, as indexed by both the number of episodes and number of MD symptoms. Patients reporting suicidal thoughts, plans or attempts experienced a significantly greater number of stressful life events. The depressive symptom most strongly associated with lifetime suicide attempt was feelings of worthlessness (odds ratio 4.25, 95% confidence interval 2.9–6.3). Excessive guilt, diminished concentration and impaired decision-making were also significantly associated with a suicide attempt.ConclusionsThis study contributes to the existing literature on risk factors for suicidal symptomatology in depressed women. Identifying specific depressive symptoms and co-morbid psychiatric disorders may help improve the clinical assessment of suicide risk in depressed patients. These findings could be helpful in identifying those who need more intense treatment strategies in order to prevent suicide.
18 citations
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TL;DR: In this paper, depression can be viewed as an adaptation to conserve energy after the perceived loss of an investment in a vital resource such as a relationship, group identity, or personal asset.
Abstract: We propose that depression can be viewed as an adaptation to conserve energy after the perceived loss of an investment in a vital resource such as a relationship, group identity, or personal asset. Tendencies to process information negatively and experience strong biological reactions to stress (resulting from genes, trauma, or both) can lead to depressogenic beliefs about the self, world, and future. These tendencies are mediated by alterations in brain areas/networks involved in cognition and emotion regulation. Depressogenic beliefs predispose individuals to make cognitive appraisals that amplify perceptions of loss, typically in response to stressors that impact available resources. Clinical features of severe depression (e.g., anhedonia, anergia) result from these appraisals and biological reactions that they trigger (e.g., autonomic, immune, neurochemical). These symptoms were presumably adaptive in our evolutionary history, but are maladaptive in contemporary times. Thus, severe depression can be c...
280 citations
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TL;DR: Based on the largest sample of patients with factitious disorder analyzed to date, the findings offer an important first step toward an evidence-based approach to the disorder.
88 citations
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TL;DR: A heterogeneous course and background of maternal depressive symptoms is suggested, which should be considered in intervention planning.
54 citations
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TL;DR: Vasopressin has a role in enhancing empathy among individuals who received higher levels of paternal warmth and no main or interaction effects were found forindividuals who received oxytocin.
49 citations
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Wellcome Trust Centre for Human Genetics1, Virginia Commonwealth University2, Shanghai Mental Health Center3, XinHua Hospital4, Shanxi Medical University5, China Medical University (PRC)6, Capital Medical University7, Sun Yat-sen University8, Jiangsu University9, Harbin Medical University10, Chongqing Medical University11, Sichuan University12, Lanzhou University13, Shantou University14, Tongji University15, Jinan University16, Tianjin First Center Hospital17
TL;DR: Prior cross-cultural studies, factor analyses of MD in Western populations and empirical findings in this sample showing risk factor profiles similar to those seen inWestern populations suggest that the results are likely to be broadly representative of the human depressive syndrome.
Abstract: Background The symptoms of major depression (MD) are clinically diverse. Do they form coherent factors that might clarify the underlying nature of this important psychiatric syndrome? Method Symptoms at lifetime worst depressive episode were assessed at structured psychiatric interview in 6008 women of Han Chinese descent, age ⩾30 years with recurrent DSM-IV MD. Exploratory factor analysis (EFA) and confirmatoryfactor analysis (CFA) were performed in Mplus in random split-half samples. Results The preliminary EFA results were consistently supported by the findings from CFA. Analyses of the nine DSM-IV MD symptomatic A criteria revealed two factors loading on: (i) general depressive symptoms; and (ii) guilt/suicidal ideation. Examining 14 disaggregated DSM-IV criteria revealed three factors reflecting: (i) weight/appetite disturbance; (ii) general depressive symptoms; and (iii) sleep disturbance. Using all symptoms (n = 27), we identified five factors that reflected: (i) weight/appetite symptoms; (ii) general retarded depressive symptoms; (iii) atypical vegetative symptoms; (iv) suicidality/hopelessness; and (v) symptoms of agitation and anxiety. Conclusions MD is a clinically complex syndrome with several underlying correlated symptom dimensions. In addition to a general depressive symptom factor, a complete picture must include factors reflecting typical/atypical vegetative symptoms, cognitive symptoms (hopelessness/suicidal ideation), and an agitated symptom factor characterized by anxiety, guilt, helplessness and irritability. Prior cross-cultural studies, factor analyses of MD in Western populations and empirical findings in this sample showing risk factor profiles similar to those seen in Western populations suggest that our results are likely to be broadly representative of the human depressive syndrome.
47 citations