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Y. F. Sasaki
Publications - 4
Citations - 4583
Y. F. Sasaki is an academic researcher. The author has contributed to research in topics: Chemistry & Comet assay. The author has an hindex of 1, co-authored 1 publications receiving 4336 citations.
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Journal ArticleDOI
Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing.
Raymond R. Tice,E. Agurell,Diana Anderson,B. Burlinson,Andreas Hartmann,H. Kobayashi,Y. Miyamae,Emilio Rojas,J.-C. Ryu,Y. F. Sasaki +9 more
TL;DR: The expert panel reached a consensus that the optimal version of the Comet assay for identifying agents with genotoxic activity was the alkaline (pH > 13) versions of the assay developed by Singh et al.
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How Bulky of Base Adducts can be Responsible for Clastogenicity rather than Mutagenicity?
TL;DR: In this article , human lymphoblstoid WTK1 cells were used to consider how bulky n- alkylated bases can induce SG mutants, and n-alkyl methanesulfonates having n-Alkyl groups with ≥ 4 carbons have been shown to induce bulky adducts that cause disturbances to the helical DNA structure and are removed by nucleotide excision repair.
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Establishment of Optimal Conditions to Extract Bioactive Substances from Gamazumi Using Supercritical Carbon Dioxide
Kumiko Sato,Takayuki Saito,Akira Hasegawa,Yoshihiro Kadoma,Marina Kobune,Y Sato,Satomi Kawaguchi,Ayumi Yamamoto,Kazuyuki Furuya,Takanori Nakamura,Y. F. Sasaki +10 more
TL;DR: In this paper , the supercritical carbon dioxide was used to extract vitamins E and stigmasterols from Gamazumi fruits to suppress the adverse effects of oxidative stress in rats.
Journal ArticleDOI
Inhibiting and Enhancing Effects on DNA Repair of Rare Metal Elements in Cultured Human Lymphoblastoid Cells
Ayaka Sasaki,Satomi Hayashi-Shita,Takanori Nakamura,Yasuaki Kikuchi,Galbreath Hannah Elizabeth,Katsutoshi Matsumoto,Akira Hasegawa,Takayuki Saito,Kumiko Sato,T. Honma,Ayumi Yamamoto,Hirotada Arai,Yoshihiro Kadoma,Satomi Kawaguchi,Kazuyuki Furuya,Marina Kobune,Y. F. Sasaki +16 more
TL;DR: Six REs, Tm, Sm, Tb, Gd, Eu, and Y suppressed comet positive responses with and without araC, suggesting that they decreased comet assay detectable SSBs and that only La would enhance the incision step of NER.