Ya-Ping Liu

Bio: Ya-Ping Liu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Alstonia scholaris & Indole test. The author has an hindex of 22, co-authored 93 publications receiving 1458 citations. Previous affiliations of Ya-Ping Liu include Kunming Institute of Botany & Kunming University of Science and Technology.

Melodinines A-G, Monoterpenoid Indole Alkaloids from Melodinus henryi

Abstract: Nineteen monoterpenoid indole alkaloids including seven new ones, melodinines A−G (1−7), were isolated from Melodinus henryi. The structures of the new compounds were elucidated using spectroscopic methods, and the structure of compound 4 was confirmed by single-crystal X-ray diffraction analysis. The known compounds were identified by comparing their spectroscopic data with those reported in the literature. All of the compounds were evaluated for cytotoxic activity against five human cancer cell lines, and compound 11 exhibited cytotoxicity against HL-60, SMMC-7721, A-549, and SK-BR-3 cells with IC50 values of 2.0, 16.8, 25.9, and 24.7 μM, respectively.

Melokhanines A–J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus

Abstract: The new melokhanines A–J (1–10) and 22 known (11–32) alkaloids were isolated from the twigs and leaves of Melodinus khasianus. The new compounds and their absolute configurations were elucidated by extensive analysis of spectroscopic, X-ray diffraction, and computational data. Melokhanine A (1), composed of a hydroxyindolinone linked to an octahydrofuro[2,3-b]pyridine moiety, is an unprecedented monoterpenoid indole alkaloid. Melokhanines B–H (2–8) possess a new 6/5/5/6/6 pentacyclic indole alkaloid skeleton. Alkaloids 1–16, 25–27, 31, and 32 showed the best antibacterial activity against Pseudomonas aeruginosa (MIC range 2–22 μM). Among the seven dermatophytes tested, compound 1 showed significant inhibitory activity against Microsporum canis, M. ferrugineum, and Trichophyton ajelloi (MIC range 38–150 μM), i.e., half the efficacy of the positive control, griseofulvin.

Melodinines M-U, cytotoxic alkaloids from Melodinus suaveolens.

Abstract: Nine new alkaloids, melodinines M-U (1-9), and 11 known alkaloids were isolated from Melodinus suaveolens. The new structures were elucidated by extensive NMR and mass spectroscopic analyses and comparison to known compounds. All compounds were evaluated for their cytotoxicity against five human cancer cell lines. Compounds 6, 11, and 16 showed significant cytotoxicity.

Cytotoxic indole alkaloids from Melodinus tenuicaudatus.

Abstract: Four new bisindole alkaloids, melodinines H-K (1-4), a new monomer, melodinine L (5), and 11 known alkaloids were isolated from Melodinus tenuicaudatus. The structures of 1-5 were elucidated by extensive spectroscopic methods, and the known compounds were identified by comparison with data in the literature. All of the compounds were evaluated for their cytotoxicity against five human cancer cell lines. Alkaloids 1, 3, and 4 and the known compound 11-methoxytabersonine (8) exhibited inhibitory effects, with IC(50) values comparable to those of cisplatin and vinorelbine.

Using Singlet Oxygen to Synthesize Natural Products and Drugs

Abstract: This Review describes singlet oxygen (1O2) in the organic synthesis of targets on possible 1O2 biosynthetic routes. The visible-light sensitized production of 1O2 is not only useful for synthesis; it is extremely common in nature. This Review is intended to draw a logical link between flow and batch reactions—a combination that leads to the current state of 1O2 in synthesis.

Plant-derived anticancer agents: A green anticancer approach

Abstract: Cancer is a frightful disease and represents one of the biggest health-care issues for the human race and demands a proactive strategy for cure. Plants are reservoirs for novel chemical entities and provide a promising line for research on cancer. Hitherto, being effective, chemotherapy is accompanied by certain unbearable side effects. Nevertheless, plants and plant derived products is a revolutionizing field as these are Simple, safer, eco-friendly, low-cost, fast, and less toxic as compared with conventional treatment methods. Phytochemicals are selective in their functions and acts specifically on tumor cells without affecting normal cells. Carcinogenesis is complex phenomena that involves many signaling cascades. Phytochemicals are considered suitable candidates for anticancer drug development due to their pleiotropic actions on target events with multiple manners. The research is in progress for developing potential candidates (those can block or slow down the growth of cancer cells without any side effects) from these phytochemicals. Many phytochemicals and their derived analogs have been identified as potential candidates for anticancer therapy. Effort has been made through this comprehensive review to highlight the recent developments and milestones achieved in cancer therapies using phytomolecules with their mechanism of action on nuclear and cellular factors. Furthermore, drugs for cancer treatment and their limitations have also been discussed.