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Author

Yan-Guang Wang

Other affiliations: Zhejiang Gongshang University
Bio: Yan-Guang Wang is an academic researcher from Zhejiang University. The author has contributed to research in topics: Nitrile & Cycloaddition. The author has an hindex of 7, co-authored 23 publications receiving 345 citations. Previous affiliations of Yan-Guang Wang include Zhejiang Gongshang University.

Papers
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Journal ArticleDOI
TL;DR: The results revealed the Akt and MAPK pathways were involved in the tumorigenesis of CD133(+) colon cancer cells, suggesting that molecules in these two pathways might be potential targets in the future therapy.
Abstract: Cancer stem cells (CSCs) play an important role in carcinogenesis, resistance to treatment and may lead to cancer recurrence and metastasis. However, the molecular mechanism of CSC involved in these events needs to be further elucidated. In this study, CD133(+) colon cancer cells were cultured, which showed CSC properties both in vitro and in vivo from metastatic tissue. Upstream molecules in Akt and mitogen-activated protein kinase (MAPK) pathways were preferentially expressed in these CD133(+) cells, as revealed by a global gene chip. The kinase activities of Akt and extracellular signal-regulated kinase (Erk)1/2 were also significantly upregulated in CD133(+) cells. In addition, the clonogenic growth of CD133(+) cell was reduced greatly by inhibiting the activity of Akt and Erk1/2. The results revealed the Akt and MAPK pathways were involved in the tumorigenesis of CD133(+) colon cancer cells, suggesting that molecules in these two pathways might be potential targets in the future therapy.

109 citations

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TL;DR: In this article, TEMPO-linked porphyrins and metalloporphyrin were synthesized and they exhibited efficient catalytic activity for selective oxidation of alcohols and sulfides to the corresponding aldehydes, ketones and sulfoxides using NaOCl as oxidant.

54 citations

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TL;DR: In this paper, the tetrahydropyranyl (THP) group was efficiently removed using PdCl 2 (CH 3 CN) 2 as catalyst in CH 3 CN, while other protection groups such as p -toluenesulfonyl (Ts), tert-butyldiphenylsilyl (TBDPS), benzyloxycarbonyl, allyl, benzyl (Bn), and benzoyl (Bz) remained intact under these conditions.

47 citations

Journal ArticleDOI
TL;DR: In this paper, the first soluble polymer-supported synthesis of isoxazoles through a 1,3-dipolar cycloaddition was described, where a soluble polymer supported alkyne reacts with nitrile oxides generated in situ to give isoxozoles in good yield.

38 citations

Journal ArticleDOI
TL;DR: Chiral N-heterocyclic carbenes (NHC) were synthesized from naturally occurring podophyllotoxin and their coordination with [(η3-allyl)Pd(Br)]2 was established by X-ray single crystal analysis.
Abstract: Chiral N-heterocyclic carbenes (NHC) were synthesized from naturally occurring podophyllotoxin. Their coordination with [(η3-allyl)Pd(Br)]2 afforded (NHC)Pd(allyl)Br complexes, whose structures were unambiguously established by X-ray single crystal analysis. These chiral NHC and NHC-Pd-allyl complexes were found to catalyze the substitution reaction of allylic compounds with high conversions and enantioselectivities (up to 87% ee).

26 citations


Cited by
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Journal ArticleDOI
TL;DR: Semisynthesis processes of new compounds, obtained by molecular modification of the functional groups of lead compounds, are able to generate structural analogues with greater pharmacological activity and with fewer side effects.
Abstract: Throughout history, natural products have afforded a rich source of compounds that have found many applications in the fields of medicine, pharmacy and biology. Within the sphere of cancer, a number of important new commercialised drugs have been obtained from natural sources, by structural modification of natural compounds, or by the synthesis of new compounds, designed following a natural compound as model. The search for improved cytotoxic agents continues to be an important line in the discovery of modern anticancer drugs. The huge structural diversity of natural compounds and their bioactivity potential have meant that several products isolated from plants, marine flora and microorganisms can serve as “lead” compounds for improvement of their therapeutic potential by molecular modification. Additionally, semisynthesis processes of new compounds, obtained by molecular modification of the functional groups of lead compounds, are able to generate structural analogues with greater pharmacological activity and with fewer side effects. These processes, complemented with high-throughput screening protocols, combinatorial chemistry, computational chemistry and bioinformatics are able to afford compounds that are far more efficient than those currently used in clinical practice. Combinatorial biosynthesis is also applied for the modification of natural microbial products. Likewise, advances in genomics and the advent of biotechnology have improved both the discovery and production of new natural compounds.

617 citations

Journal ArticleDOI
TL;DR: Alkoxyamines derived from nitroxides are shown to be highly useful precursors of C-centered radicals in synthesis and also in polymer chemistry, and new developments in the synthesis of complex polymer architectures are highlighted.
Abstract: This Review describes the application of nitroxides to synthesis and polymer chemistry. The synthesis and physical properties of nitroxides are discussed first. The largest section focuses on their application as stoichiometric and catalytic oxidants in organic synthesis. The oxidation of alcohols and carbanions, as well as oxidative C-C bond-forming reactions are presented along with other typical oxidative transformations. A section is also dedicated to the extensive use of nitroxides as trapping reagents for C-centered radicals in radical chemistry. Alkoxyamines derived from nitroxides are shown to be highly useful precursors of C-centered radicals in synthesis and also in polymer chemistry. The last section discusses the basics of nitroxide-mediated radical polymerization (NMP) and also highlights new developments in the synthesis of complex polymer architectures.

549 citations

Journal ArticleDOI
TL;DR: New insights into CD133 regulation and the involvement of CD133 in cell self-renewal, tumorigenesis, metastasis, resistance, metabolism, differentiation, autophagy, apoptosis, and regeneration are summarized.
Abstract: Cancer stem cells (CSCs) or tumor initiating cells (TICs) contribute to tumorigenesis, metastasis, recurrence and chemoresistance. CD133, a pentaspan membrane glycoprotein, has been used as a stem cell biomarker for isolation of stem-like cells from a variety of normal and pathological tissues as well as cell lines since its discovery in 1999. Recent studies are focusing on the functionality of CD133. In this review, we summarize new insights into CD133 regulation and the involvement of CD133 in cell self-renewal, tumorigenesis, metastasis, resistance, metabolism, differentiation, autophagy, apoptosis, and regeneration.

252 citations

01 Jan 2004
TL;DR: Mononuclear palladium-allyl complexes bearing one N-heterocyclic carbene (NHC) ligand have been synthesized in this article, which offer a straightforward entryway into a number of catalytic cycles by simple action of a base.
Abstract: Mononuclear palladium-allyl complexes bearing one N-heterocyclic carbene (NHC) ligand have been synthesized. These complexes offer a straightforward entryway into a number of catalytic cycles by simple action of a base.

241 citations