Y
Yan Liang
Researcher at University of Toronto
Publications - 248
Citations - 11980
Yan Liang is an academic researcher from University of Toronto. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 33, co-authored 49 publications receiving 11127 citations. Previous affiliations of Yan Liang include University Health Network & Sunnybrook Health Sciences Centre.
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Journal ArticleDOI
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
R. Sherrington,Evgeny I. Rogaev,Yan Liang,Ekaterina Rogaeva,G. Levesque,M. Ikeda,H. Chi,Chih-Ping Lin,Gavin Li,K. Holman,T. Tsuda,L. Mar,J. F. Foncin,Amalia C. Bruni,Mp Montesi,Sandro Sorbi,Innocenzo Rainero,Lorenzo Pinessi,L. Nee,Ilya Chumakov,Daniel A. Pollen,A. Brookes,Philippe Sanseau,R. Polinsky,Wilma Wasco,H. A. R. Da Silva,Jonathan L. Haines,Margaret A. Pericak-Vance,Rudolph E. Tanzi,A. D. Roses,Paul E. Fraser,Johanna M. Rommens,P. St. George-Hyslop +32 more
TL;DR: A minimal cosegregating region containing the AD3 gene is defined, and at least 19 different transcripts encoded within this region corresponds to a novel gene whose product is predicted to contain multiple transmembrane domains and resembles an integral membrane protein.
Journal ArticleDOI
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
Evgeny I. Rogaev,R. Sherrington,Ekaterina Rogaeva,G. Levesque,M. Ikeda,Yan Liang,H. Chi,Chih-Ping Lin,K. Holman,T. Tsuda,L. Mar,Sandro Sorbi,Benedetta Nacmias,Silvia Piacentini,Luigi Amaducci,Ilya Chumakov,David M. Cohen,Lars Lannfelt,Paul E. Fraser,Johanna M. Rommens,P. St. George-Hyslop +20 more
TL;DR: Analysis of the nucleotide sequence of the open reading frame of the E5-1 gene led to the discovery of two missense substitutions at conserved amino-acid residues in affected members of pedigrees with a form of familial AD that has a later age of onset than the AD3 subtype (5070 years versus 3060 years for AD3).
Journal ArticleDOI
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
Gang Yu,Masaki Nishimura,Shigeki Arawaka,Shigeki Arawaka,Diane Levitan,Lili Zhang,Anurag Tandon,Anurag Tandon,You-Qiang Song,You-Qiang Song,Ekaterina Rogaeva,Ekaterina Rogaeva,Fusheng Chen,Fusheng Chen,Toshitaka Kawarai,Toshitaka Kawarai,Agnes Supala,Agnes Supala,Lyne Levesque,Lyne Levesque,Haung Yu,Haung Yu,Dun-Sheng Yang,Dun-Sheng Yang,Erin Holmes,Erin Holmes,Paul Milman,Paul Milman,Yan Liang,Yan Liang,Dong Mel Zhang,Dong Mel Zhang,Dong Hong Xu,Dong Hong Xu,Christine Sato,Christine Sato,Evgeny I. Rogaev,Evgeny I. Rogaev,Marsha Smith,Christopher Janus,Christopher Janus,Yanni Zhang,Ruedl Aebersold,Lindsay A. Farrer,Sandro Sorbl,Amalia C. Bruni,Paul E. Fraser,Paul E. Fraser,Peter St George-Hyslop,Peter St George-Hyslop +49 more
TL;DR: Nicastrin and presenilins are likely to be functional components of a multimeric complex necessary for the intramembranous proteolysis of proteins such as Notch/GLP-1 and βAPP.
Journal ArticleDOI
Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14
P. St. George-Hyslop,Jonathan L. Haines,Evgeny I. Rogaev,Evgeny I. Rogaev,M. Mortilla,M. Mortilla,G. Vaula,G. Vaula,Margaret A. Pericak-Vance,J. F. Foncin,M.P. Montesi,Amalia C. Bruni,Sandro Sorbi,Innocenzo Rainero,Lorenzo Pinessi,Daniel A. Pollen,R. Polinsky,L. Nee,James L. Kennedy,Fabio Macciardi,Ekaterina Rogaeva,Yan Liang,N. Alexandrova,Walter J. Lukiw,Karen Schlumpf,Rudolph E. Tanzi,T. Tsuda,Lindsay A. Farrer,J. M. Cantu,Ranjan Duara,Luigi Amaducci,L. Bergamini,James F. Gusella,Allen D. Roses,D. R. Crapper McLachlan +34 more
TL;DR: Evidence is provided for a major early onset FAD locus on the long arm of chromosome 14 near the markers D14S43 and D 14S53 and it is suggested that the inheritance of FAD may be more complex than had initially been suspected.
Journal ArticleDOI
The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin
Gang Yu,Fusheng Chen,G. Levesque,Masaki Nishimura,D. M. Zhang,Lyne Levesque,Ekaterina Rogaeva,Donghong Xu,Yan Liang,Monika Duthie,P. St. George-Hyslop,Paul E. Fraser +11 more
TL;DR: Restricted incorporation of the presenilin NTF and CTF along with a potentially functional ligand (β-catenin) into a multimeric complex in the ER and Golgi apparatus may provide an explanation for the regulated accumulation of the NTF or CTF.