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Yan Lu
Researcher at Zhejiang University
Publications - 125
Citations - 5052
Yan Lu is an academic researcher from Zhejiang University. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 36, co-authored 107 publications receiving 4086 citations. Previous affiliations of Yan Lu include Sir Run Run Shaw Hospital & Creighton University Medical Center.
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Journal ArticleDOI
Exosomal miR-1290 and miR-375 as Prognostic Markers in Castration-resistant Prostate Cancer
Xiaoyi Huang,Tiezheng Yuan,Meihua Liang,Meijun Du,Shu Xia,Rachel L. Dittmar,Dian Wang,William A. See,Brian A. Costello,Fernando Quevedo,Winston Tan,Debashis Nandy,Graham H. Bevan,Sherri Longenbach,Zhifu Sun,Yan Lu,Tao Wang,Stephen N. Thibodeau,Lisa A. Boardman,Manish Kohli,Liang Wang +20 more
TL;DR: Blood-based small RNAs circulating in blood could be used to predict clinical outcomes in late-stage prostate cancer patients and plasma exosomal miRNAs miR-1290 and -375 are promising prognostic biomarkers for CRPC patients are identified.
Journal ArticleDOI
A gene expression signature predicts survival of patients with stage I non-small cell lung cancer
Yan Lu,William J. Lemon,Pengyuan Liu,Yijun Yi,Carl Morrison,Ping Yang,Zhifu Sun,Janos Szoke,William L. Gerald,Mark A. Watson,Ramaswamy Govindan,Ming You +11 more
TL;DR: A gene expression signature consisting of 64 genes that is highly predictive of which stage I lung cancer patients may benefit from more aggressive therapy is identified, useful in predicting survival of stage I NSCLC and might be useful in informing treatment decisions.
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Identification of Somatic Mutations in Non-Small Cell Lung Carcinomas Using Whole-Exome Sequencing
Pengyuan Liu,Carl Morrison,Liang Wang,Dong Hai Xiong,Peter Vedell,Peng Cui,Xing Hua,Xing Hua,Feng Ding,Yan Lu,Michael A. James,John D. Ebben,Haiming Xu,Alex A. Adjei,Karen Head,Jaime Wendt Andrae,Michael Tschannen,Howard J. Jacob,Jing Pan,Qi Zhang,Francoise Van den Bergh,Haijie Xiao,Ken C. Lo,Jigar Patel,Todd Richmond,Mary Anne Watt,Thomas J. Albert,Rebecca R. Selzer,Marshall W. Anderson,Jiang Wang,Yian Wang,Sandra L. Starnes,Ping Yang,Ming You +33 more
TL;DR: Several highly mutated genes identified in the study are promising druggable targets in cancer therapy including ALK, CTNNA3, DCC, MLL3, PCDHIIX, Pik3C2B, PIK3CG and ROCK2.
Journal ArticleDOI
Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer
Pengyuan Liu,Haris G. Vikis,Daolong Wang,Yan Lu,Yian Wang,Ann G. Schwartz,Susan M. Pinney,Ping Yang,Mariza de Andrade,Gloria M. Petersen,Jonathan S. Wiest,Pamela R. Fain,Adi F. Gazdar,Colette Gaba,Henry Rothschild,Diptasri Mandal,Teresa A. Coons,Juwon Lee,Elena Kupert,Daniela Seminara,John D. Minna,Joan E. Bailey-Wilson,Xifeng Wu,Margaret R. Spitz,Timothy Eisen,Richard S. Houlston,Christopher I. Amos,Marshall W. Anderson,Ming You +28 more
TL;DR: A genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects to identify associations between common sequence variants at 15q24-25.1 and lung cancer.
Journal ArticleDOI
MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer.
Yan Lu,Ramaswamy Govindan,Liang Wang,Pengyuan Liu,Boone Goodgame,Weidong Wen,Ananth Sezhiyan,John D. Pfeifer,Ya Fei Li,Xing Hua,Yian Wang,Ping Yang,Ming You,Ming You +13 more
TL;DR: The identified miRNAs hold great potential as targets for histology-specific treatment or prevention and treatment of recurrent disease, and two miRNA signatures that are highly predictive of RFS were identified.