Yan-Ni Shi

TL;DR: A new fusion point inside the condensation domains of NRPSs is described that results in the development of the exchange unit condensation domain (XUC) concept, which enables the efficient production of peptides, even containing non-natural amino acids, in yields up to 280 mg l−1.

TL;DR: It is demonstrated that lignans, phenylpropanoid and biphenyl found in Piper wallichii may be responsible for antithrombotic effect of the titled plant.

TL;DR: This easyPACId approach (easy Promoter Activated Compound Identification) facilitates NP identification due to low interference from other NPs and allows direct bioactivity testing of supernatants containing secreted NPs, without laborious purification.

TL;DR: In this paper , the pangenome and sequence similarity networks were used to identify 1,000 BGCs belonging to 176 families and identified the most conserved families are denoted by 11 BGC classes, which are eukaryotic proteasome inhibitors, virulence factors against insects, metallophores and insect immunosuppressants.

TL;DR: NRPminer as discussed by the authors is a modification-tolerant tool for NRP discovery from large (meta)genomic and mass spectrometry datasets, which is able to identify many NRPs from different environments.