Author
Yan Wu
Bio: Yan Wu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Fermentation & Chemistry. The author has an hindex of 23, co-authored 67 publications receiving 1233 citations.
Topics: Fermentation, Chemistry, Limonoid, Medicine, Methanogenesis
Papers published on a yearly basis
Papers
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TL;DR: A comprehensive structure-activity relationship study indicated that three functional groups are essential and two motifs can be modified in sesquiterpenoids, which is comparable to the potency of artemisinin.
Abstract: Inspired by the discovery of the antimalarial drug artemisinin from a traditional Chinese medicine (TCM), a natural product library of 44 lindenane-type sesquiterpenoids was assessed for activities against the Dd2 chloroquine-resistant strain of the malaria parasite Plasmodium falciparum. These compounds were mainly isolated from plants of the Chloranthus genus, many species of which are named “Sikuaiwa” in TCM and have long been used to treat malaria. The compounds consisted of 41 sesquiterpenoid dimers and three monomers, including the 12 new dimers 1–12 isolated from Chloranthus fortunei. The results showed that 16 dimers exhibited potent antiplasmodial activities (<100 nM); in particular, compounds 1, 14, and 19 exhibited low nanomolar activities with IC50 values ranging from 1 to 7 nM, which is comparable to the potency of artemisinin, and selectivity index values toward mammalian cells greater than 500. A comprehensive structure–activity relationship study indicated that three functional groups are ...
67 citations
TL;DR: In this article, four unusually fused polycyclic sesquiterpenoid dimers, chlorahololides C−F (1−4), were isolated from the whole plant of Chloranthus holostegius.
62 citations
TL;DR: Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggenines A and B, as well as their biosynthetic precursor (-)-norsecurinine, were isolated from the roots of Flueggea virosa, and their structures and absolute configurations were elucidated by spectroscopic methods.
58 citations
TL;DR: The in vitro antifungal activities of 19 structurally diversified analogues of pseudolaric acids tested against the major pathogenic fungus Candida albicans has led to the establishment of a very clear structure-activity relationship of pseud Polarix kaempferi derivatives.
57 citations
TL;DR: Three new norlimonoids (1-3), two new tirucallane-type triterpenoids (4 and 5), and a new pimaradiene-type diterpenoid (6) were isolated from the leaves and twigs of Toona ciliata.
Abstract: Three new norlimonoids (1-3), two new tirucallane-type triterpenoids (4 and 5), and a new pimaradiene-type diterpenoid (6), along with two known limonoids and eight known tirucallane-type triterpenoids, were isolated from the leaves and twigs of Toona ciliata. Their structures were elucidated on the basis of spectroscopic data. Toonaciliatin M (6) showed moderate antifungal activity against Trichophyton rubrum with an MIC of 12.5 microg/mL.
54 citations
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1,404 citations
TL;DR: Acyclic activated alkenes/ alkynes and Asymmetric Baylis-Hillman Reaction: Earlier Developments 5495.
Abstract: 2. Essential Components: Earlier Developments 5449 2.1. Activated alkenes/alkynes 5450 2.1.1. Acyclic activated alkenes/ alkynes 5450 2.1.2. Cyclic activated alkenes 5451 2.2. Electrophiles 5451 2.3. Catalysts 5452 3. Essential Components: Recent Developments 5452 3.1. Activated Alkenes/Alkynes 5452 3.2. Electrophiles 5460 3.3. Catalysts 5477 4. Asymmetric Baylis-Hillman Reaction: Earlier Developments 5495
752 citations
TL;DR: This review aims at highlighting photochemical transformations as a tool for rapidly accessing structurally and stereochemically diverse scaffolds for complex polycyclic carbon skeletons with impressive efficiency, which are of high value in total synthesis.
Abstract: The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the involvement of electronically excited states, generated upon absorption of photons. This produces transient reactive intermediates and significantly alters the reactivity of a chemical compound. The input of energy provided by light thus offers a means to produce strained and unique target compounds that cannot be assembled using thermal protocols. This review aims at highlighting photochemical transformations as a tool for rapidly accessing structurally and stereochemically diverse scaffolds. Synthetic designs based on photochemical transformations have the potential to afford complex polycyclic carbon skeletons with impressive efficiency, which are of high value in total synthesis.
692 citations
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, as to provide real-time information about concrete mechanical properties such as E-modulus and compressive strength.
Abstract: Natural Science Foundation of China[30000213, 30370160, 30670214]; National Basic Research Program of China (973 Program)[2009CB522300]; Chinese Academy of Sciences
372 citations