Y
Yang Wang
Researcher at Discovery Institute
Publications - 18
Citations - 4150
Yang Wang is an academic researcher from Discovery Institute. The author has contributed to research in topics: Embryonic stem cell & Gene. The author has an hindex of 11, co-authored 15 publications receiving 3345 citations. Previous affiliations of Yang Wang include Laboratory of Molecular Biology & Guangzhou Institutes of Biomedicine and Health.
Papers
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Journal ArticleDOI
Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
Yu-Fei He,Bin-Zhong Li,Zheng Li,Peng Liu,Yang Wang,Qingyu Tang,Jianping Ding,Yingying Jia,Zhangcheng Chen,Lin Li,Yan Sun,Xiuxue Li,Qing Dai,Chun-Xiao Song,Kangling Zhang,Chuan He,Guoliang Xu +16 more
TL;DR: It is demonstrated that 5mC and 5hmC in DNA are oxidized to 5-carboxylcytosine (5caC) by Tet dioxygenases in vitro and in cultured cells, suggesting that oxidation of 5m C by Tet proteins followed by TDG-mediated base excision of 5caC constitutes a pathway for active DNA demethylation.
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N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
TL;DR: Two proteins are identified, the putative m6A MTase, methyltransferase-like 3 (Mettl3; ref. ), and a related but uncharacterized protein Mettl14, that function synergistically to control m 6A formation in mammalian cells.
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N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.
Yang Wang,Yue Li,Minghui Yue,Jun Wang,Sandeep Kumar,Robert J. Wechsler-Reya,Zhaolei Zhang,Yuya Ogawa,Yuya Ogawa,Manolis Kellis,Gregg Duester,Jing Crystal Zhao +11 more
TL;DR: An essential function for m6A mRNA modification in promoting neural stem cell proliferation is demonstrated and interactions between m 6A and histone modification as a novel gene regulatory mechanism are revealed.
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The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells
Deobrat Dixit,Briana C. Prager,Briana C. Prager,Briana C. Prager,Ryan C. Gimple,Ryan C. Gimple,Hui Xian Poh,Yang Wang,Qiulian Wu,Zhixin Qiu,Reilly L. Kidwell,Leo J.Y. Kim,Leo J.Y. Kim,Qi Xie,Kristoffer Vitting-Seerup,Shruti Bhargava,Zhen Dong,Li Jiang,Zhe Zhu,Petra Hamerlik,Samie R. Jaffrey,Jing Crystal Zhao,Xiuxing Wang,Jeremy N. Rich,Jeremy N. Rich +24 more
TL;DR: YTHDF2 links RNA epitranscriptomic modifications and GSC growth, laying the foundation for the YTHDF 2-MYC-IGFBP3 axis as a specific and novel therapeutic target in glioblastoma.
Journal ArticleDOI
Reprogramming of mouse and human somatic cells by high-performance engineered factors
Yang Wang,Yang Wang,Jiekai Chen,Jia‐Lei Hu,Xi‐Xiao Wei,Dajiang Qin,Juan Gao,Zhang Lei,Jing Jiang,Jinsong Li,Jing Liu,Keyu Lai,Xia Kuang,Jian Zhang,Duanqing Pei,Guoliang Xu +15 more
TL;DR: In this paper, the VP16 transactivation domain was fused to OCT4, NANOG, and SOX2, and these synthetic factors could reprogramme both mouse and human fibroblasts with enhanced efficiency.