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Yang Xin Fu
Researcher at University of Texas Southwestern Medical Center
Publications - 404
Citations - 41503
Yang Xin Fu is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 97, co-authored 390 publications receiving 33526 citations. Previous affiliations of Yang Xin Fu include Washington University in St. Louis & Johns Hopkins University.
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Journal ArticleDOI
Innate and adaptive immune cells in the tumor microenvironment
TL;DR: Two broad categories of tumor escape based on cellular and molecular characteristics of the tumor microenvironment are suggested, which appear to resist immune attack through immune system exclusion or ignorance and may require distinct immunotherapeutic interventions for maximal therapeutic effect.
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Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice
Liufu Deng,Hua Liang,Byron Burnette,Michael A. Beckett,Thomas E. Darga,Ralph R. Weichselbaum,Yang Xin Fu +6 more
TL;DR: Evidence is provided for a close interaction between IR, T cells, and the PD-L1/PD-1 axis and a basis for the rational design of combination therapy with immune modulators and radiotherapy is established.
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STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
Liufu Deng,Hua Liang,Meng Xu,Xuanming Yang,Byron Burnette,Ainhoa Arina,Xiao Dong Li,Helena J. Mauceri,Michael A. Beckett,Thomas E. Darga,Xiaona Huang,Thomas F. Gajewski,Zhijian J. Chen,Yang Xin Fu,Ralph R. Weichselbaum +14 more
TL;DR: Radiation-mediated antitumor immunity in immunogenic tumors requires a functional cytosolic DNA-sensing pathway and suggests that cGAMP treatment might provide a new strategy to improve radiotherapy.
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Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment
Youjin Lee,Sogyong L. Auh,Yugang Wang,Byron Burnette,Yang Wang,Yuru Meng,Michael A. Beckett,Rohit Sharma,Robert K. Chin,Tony Tu,Ralph R. Weichselbaum,Yang Xin Fu +11 more
TL;DR: It is reported that reduction of tumor burden after ablative RT depends largely on T-cell responses, and the need for new strategies that not only reduce tumor burden but also enhance the role of antitumor immunity is emphasized.
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Radiotherapy and immunotherapy: a beneficial liaison?
TL;DR: Data that provide new mechanistic explanations for the success or failure of radiotherapy are highlighted, and how the combination of immune-modulation and radiation could tip the balance of the host immune response to promote cure is postulated.