Yang Yang

Bio: Yang Yang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Computer science. The author has an hindex of 171, co-authored 2644 publications receiving 153049 citations. Previous affiliations of Yang Yang include Zhejiang University & Northwest Normal University.

Vertically integrated electronic circuits via a combination of self-assembled polyelectrolytes, ink-jet printing, and electroless metal plating processes

Abstract: The advantages of polymers are the fabrication and patterning of ultra-large-area coatings. In this paper, an approach which combines self-assembled polyelectrolytes, ink-jet printing, and electroless metal plating technologies for the fabrication of vertically integrated electronic circuits is successfully demonstrated. Through these processes, several layers of metal integrated circuits were deposited sequentially with polymer layers sandwiched between each layer of wires. Hence, one can build vertically integrated electronic components consisting of diodes, capacitors, resistors, and inductors with a relatively simple and low-cost technology.

Synthesis and photocatalytic properties of core–shell structured α-Fe2O3@SnO2 shuttle-like nanocomposites

Abstract: The core–shell structured α-Fe2O3@SnO2 shuttle-like nanocomposites were synthesized successfully by a simple solvothermal method. The structure and morphology were investigated by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive spectroscopy (EDS). The results reveal that the diameter in the middle part and the length of the heteronanostructures are respectively 110 and 450 nm, and the thickness of the shell composed of 5 nm SnO2 nanoparticles is about 15 nm. The photocatalytic activities of the as-prepared α-Fe2O3@SnO2 core–shell shuttle-like nanocomposites were evaluated by the photocatalytic decolorization of a model pollutant Rhodamine-B (RhB) under ultraviolet light. The as-prepared core–shell shuttle-like nanocomposites showed much higher photocatalytic activity than that of α-Fe2O3 shuttle-like nanorods, SnO2 nanoparticles, and the mixture of α-Fe2O3 nanorods and SnO2 particles, which may be attributed to effective synergy between α-Fe2O3 and SnO2, and the special core–shell structures.

TNFα-YAP/p65-HK2 axis mediates breast cancer cell migration

Abstract: Clinical and experimental evidence indicates that macrophages could promote solid-tumor progression and metastasis. However, the mechanisms underlying this process remain unclear. Here we show that yes-associated protein 1 (YAP1), a transcriptional regulator that controls tissue growth and regeneration, has an important role in tumor necrosis factor α (TNF α)-induced breast cancer migration. Mechanistically, macrophage conditioned medium (CM) or TNFα triggers IκB kinases (IKKs)-mediated YAP phosphorylation and activation in breast cancer cells. We further found that TNFα or macrophage CM treatment increases the interaction between p65 and YAP. Chromatin immunoprecipitation (ChIP) assay shows that YAP/TEAD (TEA domain family member) and p65 proteins synergistically regulate the transcription of hexokinase 2 (HK2), a speed-limiting enzyme in glycolysis, and promotes TNFα-induced or macrophage CM-induced cell migration. Together, our findings indicate an important role of TNFα-IKK-YAP/p65-HK2 signaling axis in the process of inflammation-driven migration in breast cancer cells, which reveals a new molecular link between inflammation and breast cancer metastasis.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

Fast parallel algorithms for short-range molecular dynamics

Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

Electronics and optoelectronics of two-dimensional transition metal dichalcogenides.

Abstract: Single-layer metal dichalcogenides are two-dimensional semiconductors that present strong potential for electronic and sensing applications complementary to that of graphene.