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Yang Yang

Bio: Yang Yang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Computer science. The author has an hindex of 171, co-authored 2644 publications receiving 153049 citations. Previous affiliations of Yang Yang include Zhejiang University & Northwest Normal University.


Papers
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TL;DR: In this article , the authors measured nAb titres across 411 sequential plasma samples collected during 1-480 d after illness onset or laboratory confirmation (d.a.o.) from 214 COVID-19 convalescents, covering the clinical spectrum of disease and without additional exposure history after recovery or vaccination against SARS-CoV-2.
Abstract: Elucidating the dynamics of the neutralizing antibody (nAb) response in coronavirus disease 2019 (COVID-19) convalescents is crucial in controlling the pandemic and informing vaccination strategies. Here we measured nAb titres across 411 sequential plasma samples collected during 1-480 d after illness onset or laboratory confirmation (d.a.o.) from 214 COVID-19 convalescents, covering the clinical spectrum of disease and without additional exposure history after recovery or vaccination against SARS-CoV-2, using authentic SARS-CoV-2 microneutralization (MN) assays. Forty-eight samples were also tested for neutralizing activities against the circulating variants using pseudotyped neutralization assay. Results showed that anti-RBD IgG and MN titres peaked at ~120 d.a.o. and subsequently declined, with significantly reduced nAb responses found in 91.67% of COVID-19 convalescents (≥50% decrease in current MN titres compared with the paired peak MN titres). Despite this decline, majority of the COVID-19 convalescents maintained detectable anti-RBD IgG and MN titres at 400-480 d.a.o., with undetectable neutralizing activity found in 14.41% (16/111) of the mild and 50% (5/10) of the asymptomatic infections at 330-480 d.a.o. Persistent antibody-dependent immunity could provide protection against circulating variants after one year, despite significantly decreased neutralizing activities against Beta, Delta and Mu variants. In conclusion, these data show that despite a marked decline in neutralizing activity over time, nAb responses persist for up to 480 d in most convalescents of symptomatic COVID-19, whereas a high rate of undetectable nAb responses was found in convalescents from asymptomatic infections.

53 citations

Journal ArticleDOI
16 Oct 2014-PLOS ONE
TL;DR: In this article, the authors identify a role for histone deacetylse 6 (HDAC6) in lipopolysaccharide (LPS)-induced macrophage activation and show that suppression of HDAC6 activity significantly restrains LPS-induced activation of macrophages and production of pro-inflammatory cytokines.
Abstract: Activated macrophages play an important role in both innate and adaptive immune responses, and aberrant activation of macrophages often leads to inflammatory and immune disorders. However, the molecular mechanisms of how macrophages are activated are not fully understood. In this study, we identify a novel role for histone deacetylse 6 (HDAC6) in lipopolysaccharide (LPS)-induced macrophage activation. Our data show that suppression of HDAC6 activity significantly restrains LPS-induced activation of macrophages and production of pro-inflammatory cytokines. Further study reveals that the regulation of macrophage activation by HDAC6 is independent of F-actin polymerization and filopodium formation; instead, it is mediated by the effects of HDAC6 on cell adhesion and microtubule acetylation. These data thus suggest that HDAC6 is an important regulator of LPS-induced macrophage activation and might be a potential target for the management of inflammatory disorders.

53 citations

Journal ArticleDOI
TL;DR: Investigation of the optical and optoelectronic properties of perovskite single crystals found that appropriate incorporation of Br is useful in the design of better PV devices and confirmed that the ultralong carrier lifetime was ascribed to the integrated superiority derived from both the low trap-state density and high charge-injection efficiency of the device interface.
Abstract: The long carrier lifetimes in perovskite single crystals have drawn significant attention recently on account of their irreplaceable contribution to high-performance photovoltaic (PV) devices. Herein, the optical and optoelectronic properties of CH3NH3PbI3 and CH3NH3PbI3–xBrx (with five different contents of Br doped) single crystals were investigated. Notably, a superior carrier lifetime of up to 262 μs was observed in the CH3NH3PbI3–xBrx (I/Br = 10:1 in the precursor) single-crystal PV device under 1 sun illumination, which is two times longer than that in the CH3NH3PbI3 single crystal. Further study confirmed that the ultralong carrier lifetime was ascribed to the integrated superiority derived from both the low trap-state density and high charge-injection efficiency of the device interface. On this basis, appropriate incorporation of Br is useful in the design of better PV devices.

53 citations

Journal ArticleDOI
TL;DR: A novel distributed multi-priority congestion control method to maximize the transmission opportunities for the highest priority traffics while keeping the collision probability at a low level is proposed.
Abstract: This article surveys a collection of representative congestion control approaches for the IEEE 802.11p vehicular network. Challenges remaining in the current literature are concluded. We then propose a novel distributed multi-priority congestion control method to maximize the transmission opportunities for the highest priority traffics while keeping the collision probability at a low level. Open issues for the future work on the congestion control approach design are drawn at the end of this article.

53 citations

Journal ArticleDOI
TL;DR: This paper formulate the problem of energy- efficient routing for signal detection under the Neyman-Pearson criterion, apparently for the first time, and proposes three different routing metrics that aim at an appropriate tradeoff between the detection performance and the energy expenditure.
Abstract: For many envisioned applications of wireless sensor networks (WSNs), the information processing involves dealing with distributed data in the context of accurate signal detection and energy-efficient routing, which have been active research topics for many years, respectively. In this paper, we relate these two aspects via joint optimization. Considering the scenario of using distributed radar-like sensors to detect the presence of an object through active sensing, we formulate the problem of energy- efficient routing for signal detection under the Neyman-Pearson criterion, apparently for the first time. The joint optimization of detection and routing is carried out in a fusion center which precomputes the routes as a function of the geographic location to be monitored. Accordingly, we propose three different routing metrics that aim at an appropriate tradeoff between the detection performance and the energy expenditure. In particular, each metric relates the detection performance explicitly in terms of probabilities of detection and false alarm, with the energy consumed in sensing and routing. The routing problems are formulated as combinatorial optimization programs, and we provide solutions drawing on operations research. We present extensive simulation results that demonstrate the energy and detection performance tradeoffs for each proposed routing metric.

53 citations


Cited by
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[...]

08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

01 May 1993
TL;DR: Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems.
Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

29,323 citations

28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

18,940 citations

Journal ArticleDOI
TL;DR: This work reviews the historical development of Transition metal dichalcogenides, methods for preparing atomically thin layers, their electronic and optical properties, and prospects for future advances in electronics and optoelectronics.
Abstract: Single-layer metal dichalcogenides are two-dimensional semiconductors that present strong potential for electronic and sensing applications complementary to that of graphene.

13,348 citations