Yang Yang

Bio: Yang Yang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Computer science. The author has an hindex of 171, co-authored 2644 publications receiving 153049 citations. Previous affiliations of Yang Yang include Zhejiang University & Northwest Normal University.

Emerging agents and regimens for multiple myeloma

Abstract: The outcomes of multiple myeloma (MM) have been improved significantly with the therapies incorporating proteasome inhibitors (PI), immunomodulatory drugs, monoclonal antibodies (MoAb) and stem cell transplantation. However, relapsed and refractory MM (RRMM) remains a major challenge. Novel agents and regimens are under active clinical development. These include new PIs such as ixazomib, marizomib, and oprozomib; new MoAbs such as isatuximab and MOR202; novel epigenetic agent ricolinostat and novel cytokines such as siltuximab. Recently, the first XPO-1 inhibitor, selinexor, was approved for RRMM. BCMA-targeted BiTE, antibody–drug conjugates and CAR-T cells have the potential to revolutionize the therapy for RRMM. In this review, we summarized the latest clinical development of these novel agents and regimens.

Fabrication and biological application of nano-hydroxyapatite (nHA)/alginate (ALG) hydrogel as scaffolds

Abstract: We have fabricated tubular hydrogel scaffolds of nano-hydroxyapatite (nHA)/alginate (ALG) via a layer-by-layer (LbL) technique. Using Ca2+ as a crosslinker, nHA was assembled with ALG to form a hydrogel network. The inner diameter of scaffolds could be controlled from 0.5 mm to 7 mm by varying the assembled layer numbers of nHA/ALG pairs. By changing the nHA concentration, we can also control the crosslinking degree of the hydrogel network, and further change the mechanical properties, swelling behavior, permeability and diffusivity of the scaffolds. The elastic modulus of the hydrogel scaffolds was regulated from 0.98 ± 0.05 MPa to 2.78 ± 0.08 MPa as the concentration of nHA was changed from 50 mg mL−1 to 300 mg mL−1, which reached the requirements of avascular soft tissue. The diffusion coefficient was tuned from 23.84 × 10−7 cm2 s−1 to 9.92 × 10−7 cm2 s−1 for controlled mass transport in the hydrogel network. Moreover, human embryo skin fibroblast (ESF) culture experiments prove that nHA can improve cellular adhesion on the hydrogel surface. These results thus suggest that the assembled nHA/ALG hydrogel scaffolds are an attractive biomaterial for great potential application in soft tissue engineering.

Channel measurements and models for high-speed train wireless communication systems in tunnel scenarios: a survey

Abstract: The rapid developments of high-speed trains (HSTs) introduce new challenges to HST wireless communication systems. Realistic HST channel models play a critical role in designing and evaluating HST communication systems. Due to the length limitation, bounding of tunnel itself, and waveguide effect, channel characteristics in tunnel scenarios are very different from those in other HST scenarios. Therefore, accurate tunnel channel models considering both large-scale and small-scale fading characteristics are essential for HST communication systems. Moreover, certain characteristics of tunnel channels have not been investigated sufficiently. This article provides a comprehensive review of the measurement campaigns in tunnels and presents some tunnel channel models using various modeling methods. Finally, future directions in HST tunnel channel measurements and modeling are discussed.

One-step, low-temperature deposited perovskite solar cell utilizing small molecule additive

Abstract: In the current study, the perovskite absorber (CH3NH3PbI3) is processed via one-step deposition employing the small molecule additive, BmPyPhB, which can be dissolved in dimethylformamide along with precursors. Here, 1,3-Bis(3,5-di(pyridin-3-yl)phenyl)benzene (BmPyPhB) functions as the morphology controller to introduce an intermediate phase during perovskite film growth, which allows well-defined and precrystallized domains formed before the annealing treatment. Furthermore, a chloroform solvent wash procedure is applied afterward to remove BmPyPhB from perovskite without damaging the predetermined morphology. Thus, postannealing as low as 100°C for 5 min can achieve the optimal power conversion efficiency of 8% in a planar-structured inverted solar cell. © 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) (DOI: 10.1117/1.JPE.5.057405)

Polymer:metal nanoparticle devices with electrode-sensitive bipolar resistive switchings and their application as nonvolatile memory devices

Abstract: Devices with a polystyrene film blended with gold nanoparticles capped with conjugated 2-naphthalenethiol exhibited electrode-sensitive bipolar resistive switchings. The resistances of the two states could be different by almost three orders of magnitude, and the devices could be switched between the two states for numerous times. Thus, these devices can be used as nonvolatile memory devices. The resistive switching voltage is related to the work function of the electrode. The electrode sensitivity of the resistive switchings is attributed to the contact potential at the contact of gold nanoparticles and electrode arising from charge transfer between them.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

Fast parallel algorithms for short-range molecular dynamics

Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

Electronics and optoelectronics of two-dimensional transition metal dichalcogenides.

Abstract: Single-layer metal dichalcogenides are two-dimensional semiconductors that present strong potential for electronic and sensing applications complementary to that of graphene.