Yanti Octavia

TL;DR: The authors have reviewed the molecular mechanisms of the pathogenesis of acute and chronic doxorubicin-induced cardiotoxicity and propose potential pharmacological interventions and treatment options to prevent or reverse this specific type of heart failure.

TL;DR: In this paper , the authors tested the hypothesis that endogenous DNA repair in cardiomyocytes is critical for maintaining normal cardiac function, so that perturbed repair of spontaneous DNA damage drives early onset of heart failure.

TL;DR: More focused molecular analysis is needed to further unravel the mechanism of action and optimize the use of this eNOS-modulator (BH4), which is already approved as phenylketonuria (PKU) drug, in this clinical relevant model of reperfusion injury.

TL;DR: It is reported by using a swine model of pulmonary artery banding-induced right ventricular hypertrophy that the outward remodeling of the right coronary artery (RCA) induces reactive oxygen species (ROS) generation, an increase in basal activity.

TL;DR: In this article , the authors derived a BC cardiovascular risk index called the CRIB (Cardiovascular Risk Index in Breast Cancer) to estimate the risk of a major adverse cardiovascular events (MACE) in women undergoing treatment for BC.