Author
Yao Zhi
Bio: Yao Zhi is an academic researcher from East China Normal University. The author has contributed to research in topics: Derivative (chemistry) & Amine gas treating. The author has an hindex of 2, co-authored 8 publications receiving 15 citations.
Papers
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TL;DR: An FeCl3-catalyzed allenic Claisen rearrangement/regio- and chemoselective aerobic dehydrogenative cyclization domino reaction is developed, providing a wide range of 2-aryl/alkyl, 3-(substituted-vinyl)naphtho[2,1- b]furans in high yields at 95-130 °C in an atom- and step-economic fashion.
16 citations
TL;DR: The selectivity for either product is achieved by accessing unique catalytic cycles involving different valence states for cobalt, as well as through an electrophilic cobaltation(III) pathway.
9 citations
TL;DR: N,N-Disubstituted thioamides coupled with N-tosylhydrazones under Pd(TFA)2/tBuXPhos catalyst and NaOtBu, and the intermediates from palladium carbene migratory insertion containing β-hydrogen were...
4 citations
Patent•
21 Aug 2018
TL;DR: In this article, an allene thiocyanide derivative and a synthesis method of the derivative were presented. But the synthesis method was based on a two-step tandem reaction at room temperature to obtain the derivative, which has the advantages of simple operation, safety, high efficiency, mild condition and the like.
Abstract: The invention discloses an allene thiocyanide derivative and a synthesis method thereof. Propargylamine and trifluoromethylthio silver are used as raw materials, a haloid is used as an additive, an organic solvent is used as a solvent, and a two-step tandem reaction is carried out at room temperature to obtain the allene thiocyanide derivative. The synthesis method of the allene thiocyanide derivative has the advantages of simple operation, safety, high efficiency, mild condition and the like.
2 citations
Patent•
17 Aug 2018
TL;DR: In this article, an allene fluoroform thioether derivative and a synthetic method of the derivative were presented. But the method was performed at room temperature, and the reaction is performed at the temperature of 80 DEG C.
Abstract: The invention discloses an allene fluoroform thioether derivative and a synthetic method thereof. Propynylamine and fluoroform sulfur silver serve as raw materials, haloid serves as an additive, organic solvents serve as solvents, reaction is performed at room temperature, the fluoroform sulfur silver serve as the raw material is added after two-step cascade reaction, di-tert-butyl peroxide serving as an oxidizing agent is added, reaction is performed at the temperature of 80 DEG C, and the allene fluoroform thioether derivative is prepared by one-pot three-step reaction. The synthetic methodof the allene fluoroform thioether derivative can achieve the advantages of high chemical selectivity and position selectivity, simplicity in operation, safety, high efficiency and the like by condition control.
1 citations
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TL;DR: This review describes the progress of the last decade on the synthesis of substituted benzofurans, which are useful scaffolds for the synthesisof numerous natural products and pharmaceuticals, with transition-metal catalysis or metal-free processes.
Abstract: This review describes the progress of the last decade on the synthesis of substituted benzofurans, which are useful scaffolds for the synthesis of numerous natural products and pharmaceuticals. In particular, new intramolecular and intermolecular C–C and/or C–O bond-forming processes, with transition-metal catalysis or metal-free are summarized. (1) Introduction. (2) Ring generation via intramolecular cyclization. (2.1) C7a–O bond formation: (route a). (2.2) O–C2 bond formation: (route b). (2.3) C2–C3 bond formation: (route c). (2.4) C3–C3a bond formation: (route d). (3) Ring generation via intermolecular cyclization. (3.1) C7a-O and C3–C3a bond formation (route a + d). (3.2) O–C2 and C2–C3 bond formation: (route b + c). (3.3) O–C2 and C3–C3a bond formation: (route b + d). (4) Benzannulation. (5) Conclusion.
28 citations
22 citations
TL;DR: Tandem anionic oxy-Cope rearrangement/radical oxygenation reactions provide diverse δ,ε-unsaturated α-(aminoxy) carbonyl compounds that serve as convenient scaffolds to diverse compound classes.
Abstract: Tandem anionic oxy-Cope rearrangement/radical oxygenation reactions provide δ,ϵ-unsaturated α-(aminoxy) carbonyl compounds, which serve as convenient precursors to diverse compound classes. Functionalized carbocycles are accessible by very rare all-carbon 5-endo-trig cyclizations, but also common 5-exo-trig radical cyclizations, based on the persistent radical effect. The tandem reactions can be further extended by highly diastereoselective allylation or reduction steps to give complex scaffolds.
13 citations
TL;DR: A diphenyl-diselenide-mediated Claisen-type rearrangement/cyclization of propargylic aryl ethers under metal-free conditions is developed, affording various naphthofuran-2-carboxaldehydes in moderate to excellent yield.
12 citations
TL;DR: In this article , a class of ferrocene-based unsymmetrical bidentate ligands containing a di(1-adamantyl)phosphino group, Fc(PAd2)(PR2) abbreviated as MPhos ligands, and their corresponding (MPhos)PdCl2 pre-catalysts were synthesized in very good yields and fully characterized using techniques including single-crystal X-ray crystallography.
Abstract: A class of ferrocene-based unsymmetrical bidentate ligands containing a di(1-adamantyl)phosphino group, Fc(PAd2)(PR2) (R = Ph, Cy, iPr, tBu) abbreviated as MPhos ligands, and their corresponding (MPhos)PdCl2 pre-catalysts were synthesized in very good yields and fully characterized using techniques including single-crystal X-ray crystallography. These pre-catalysts were utilized for Csp2–Csp3 couplings for many kinds of name reactions such as Murahashi–Feringa, Kumada–Corriu, Negishi, and Suzuki–Miyaura with good substrate scope and isolated yields. About nine “drug-like” molecules were also tested successfully to demonstrate their potential applications in active pharmaceutical ingredient (API) synthesis. The tunability of the catalyst system enabled the matching of sterics and electronics of the ligand with that of the substrates to have desirable results for over five dozen systems in good yields and selectivity.
9 citations