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Yasuhiko Minokoshi
Researcher at National Institutes of Natural Sciences, Japan
Publications - 104
Citations - 16619
Yasuhiko Minokoshi is an academic researcher from National Institutes of Natural Sciences, Japan. The author has contributed to research in topics: Brown adipose tissue & Leptin. The author has an hindex of 48, co-authored 101 publications receiving 15494 citations. Previous affiliations of Yasuhiko Minokoshi include Graduate University for Advanced Studies & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Toshimasa Yamauchi,Junji Kamon,Yasuhiko Minokoshi,Yoichi M. Ito,Hironori Waki,S. Uchida,Shigeo Yamashita,Mitsuhiko Noda,Shunbun Kita,K Ueki,Koji Eto,Y. Akanuma,Philippe Froguel,Fabienne Foufelle,Pascal Ferré,David Carling,Shigeko Kimura,Ryozo Nagai,Barbara B. Kahn,Takashi Kadowaki +19 more
TL;DR: It is shown that phosphorylation and activation of the 5′-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length Ad in skeletal muscle and only with full- lengths Ad in the liver, indicating that stimulation of glucose utilization and fatty-acid oxidation by Ad occurs through activation of AMPK.
Journal ArticleDOI
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase.
Yasuhiko Minokoshi,Young-Bum Kim,Odile D. Peroni,Lee G.D. Fryer,Corinna Müller,David Carling,Barbara B. Kahn +6 more
TL;DR: It is shown that leptin selectively stimulates phosphorylation and activation of the α2 catalytic subunit of AMPK (α2 AMPK) in skeletal muscle, thus establishing a previously unknown signalling pathway for leptin, and identifying AMPK as a principal mediator of the effects of leptin on fatty-acid metabolism in muscle.
Journal ArticleDOI
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Yasuhiko Minokoshi,Thierry Alquier,Noboru Furukawa,Young-Bum Kim,Anna Lee,Bingzhong Xue,James Mu,Fabienne Foufelle,Pascal Ferré,Morris J. Birnbaum,Bettina J. Stuck,Barbara B. Kahn +11 more
TL;DR: Hypothalamic AMPK plays a critical role in hormonal and nutrient-derived anorexigenic and orexigenic signals and in energy balance, and inhibition of hypothalamic AM PK is necessary for leptin's effects on food intake and body weight, as constitutively active AMPK blocks these effects.
Journal ArticleDOI
PTP1B regulates leptin signal transduction in vivo.
Janice M. Zabolotny,Kendra K. Bence-Hanulec,Alain Stricker-Krongrad,Fawaz G. Haj,Yongping Wang,Yasuhiko Minokoshi,Young-Bum Kim,Joel K. Elmquist,Louis A. Tartaglia,Barbara B. Kahn,Benjamin G. Neel +10 more
TL;DR: It is shown that PTP1B regulates leptin signaling in vivo, likely by targeting Jak2, and may be a novel target to treat leptin resistance in obesity.
Journal ArticleDOI
Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake
Naoto Kubota,Wataru Yano,Tetsuya Kubota,Tetsuya Kubota,Toshimasa Yamauchi,Shinsuke Itoh,Hiroki Kumagai,Hideki Kozono,Iseki Takamoto,Shiki Okamoto,Tetsuya Shiuchi,Ryo Suzuki,Hidemi Satoh,Atsushi Tsuchida,Masao Moroi,Kaoru Sugi,Tetsuo Noda,Tetsuo Noda,Hiroyuki Ebinuma,Yoichi Ueta,Tatsuya Kondo,Eiichi Araki,Osamu Ezaki,Ryozo Nagai,Kazuyuki Tobe,Yasuo Terauchi,Kohjiro Ueki,Yasuhiko Minokoshi,Takashi Kadowaki +28 more
TL;DR: It is shown that adiponectin stimulates food intake and decreases energy expenditure during fasting through its effects in the central nervous system via its receptor AdipoR1 to stimulate food intake.