Y
Yasuhiro Yamamura
Researcher at Hiroshima University
Publications - 52
Citations - 7607
Yasuhiro Yamamura is an academic researcher from Hiroshima University. The author has contributed to research in topics: Parkinsonism & Parkin. The author has an hindex of 24, co-authored 52 publications receiving 7211 citations.
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Journal ArticleDOI
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Tohru Kitada,Shuichi Asakawa,Nobutaka Hattori,Hiroto Matsumine,Yasuhiro Yamamura,Shinsei Minoshima,Masayuki Yokochi,Yoshikuni Mizuno,Nobuyoshi Shimizu +8 more
TL;DR: Mutations in the newly identified gene appear to be responsible for the pathogenesis of Autosomal recessive juvenile parkinsonism, and the protein product is named ‘Parkin’.
Journal Article
Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27
Hiroto Matsumine,Masaaki Saito,Satoe Shimoda-Matsubayashi,Hirosato Tanaka,A. Ishikawa,Y. Nakagawa-Hattori,M. Yokochi,T Kobayashi,Shuichi Igarashi,Hiroki Takano,Kazuhiro Sanpei,R Koike,H Mori,T Kondo,Y Mizutani,Alejandro A. Schäffer,Yasuhiro Yamamura,Shigenobu Nakamura,Shigeki Kuzuhara,Shoji Tsuji,Yoshikuni Mizuno +20 more
TL;DR: Strong evidence is discovered for the localization of the AR-JP gene at chromosome 6q25, including the SOD2 locus, by linkage analysis of diallelic polymorphism of the Mn-superoxide dismutase gene (SOD2).
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Molecular genetic analysis of a novel Parkin gene in Japanese families with autosomal recessive juvenile parkinsonism: evidence for variable homozygous deletions in the Parkin gene in affected individuals.
Nobutaka Hattori,Tohru Kitada,Tohru Kitada,Hiroto Matsumine,Shuichi Asakawa,Yasuhiro Yamamura,Hiroyo Yoshino,Tomonori Kobayashi,Masayuki Yokochi,Mei Wang,Asako Yoritaka,Tomoyoshi Kondo,Shigeki Kuzuhara,Shigenobu Nakamura,Nobuyoshi Shimizu,Yoshikuni Mizuno +15 more
TL;DR: The findings indicate that loss of function of the Parkin protein results in the clinical phenotype of AR‐JP and that subregions between introns 2 and 5 of the parkin gene are mutational hot spots.
Journal ArticleDOI
Immunohistochemical and subcellular localization of parkin protein: Absence of protein in autosomal recessive juvenile parkinsonism patients
Hideki Shimura,Nobutaka Hattori,Shin-ichiro Kubo,Mutsuko Yoshikawa,Tohru Kitada,Hiroto Matsumine,Shuichi Asakawa,Shinsei Minoshima,Yasuhiro Yamamura,Nobuyoshi Shimizu,Yoshikuni Mizuno +10 more
TL;DR: Subcellular localization of Parkin protein in patients with AR‐JP or Parkinson's disease (PD) and in controls by immunoblotting and immunohistochemistry using antibodies raised against the Parkin molecule is reported.
Journal ArticleDOI
Novel PINK1 mutations in early-onset parkinsonism.
Yasuko Hatano,Yuanzhe Li,Kenichi Sato,Shuichi Asakawa,Yasuhiro Yamamura,Hiroyuki Tomiyama,Hiroyo Yoshino,Masato Asahina,Susumu Kobayashi,Sharon Hassin-Baer,Chin-Song Lu,Arlene R. Ng,Raymond L. Rosales,Nobuyoshi Shimizu,Tatsushi Toda,Yoshikuni Mizuno,Nobutaka Hattori +16 more
TL;DR: Mutation analysis in eight inbred families whose haplotypes link to the PARK6 region identified six pathogenic mutations in six unrelated families, suggesting that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance.