Yasuo Hatanaka

Bio: Yasuo Hatanaka is an academic researcher from Osaka City University. The author has contributed to research in topics: Coupling reaction & Palladium. The author has an hindex of 22, co-authored 51 publications receiving 2396 citations. Previous affiliations of Yasuo Hatanaka include Nagoya University & Tokyo Institute of Technology.

Carbon-carbon bond-forming reactions using cerium metal or organocerium(III) reagents

Abstract: L'amalgame de cerium est un reactif efficace pour la preparation chimioselective d'alcools homoallyliques a partir d'halogenures allyliques et de composes carbonyles. Ce meme reactif est utilise dans des reactions de type Reformatsky. Les reactifs organiques du Ce(III) generes par reaction d'organolithiens avec CeI 3 ou CeCl 3 sont moins basiques que les organolithiens et les reactifs de Grignard et reagissent avec divers composes carbonyles

Palladium-catalyzed cross-coupling reaction of organometalloids through activation with fluoride ion

Abstract: Activation of organosilicon compounds with fluoride ion produces a transient pentacoordinate silicate, which is capable of transmetalation with a catalytic organopalladium complex and achieves cross-coupling reaction. Mono-, di- or trifluorosilanes can deliver alkenyl, aryl, or alkyl group, respectively. The reaction, characterized by high chemo- and stereoselectivity, was successfully applied to synthesis of HMG-CoA reductase inhibitor NK-104 and functionalized biaryls for liquid crystals. The stereochemical aspects are discussed.

Palladium-Catalyzed Cross-Coupling: A Historical Contextual Perspective to the 2010 Nobel Prize

Abstract: In 2010, Richard Heck, Ei-ichi Negishi, and Akira Suzuki joined the prestigious circle of Nobel Laureate chemists for their roles in discovering and developing highly practical methodologies for C-C bond construction. From their original contributions in the early 1970s the landscape of the strategies and methods of organic synthesis irreversibly changed for the modern chemist, both in academia and in industry. In this Review, we attempt to trace the historical origin of these powerful reactions, and outline the developments from the seminal discoveries leading to their eminent position as appreciated and applied today.