Y
Yasushi Hojo
Researcher at Saitama Medical University
Publications - 58
Citations - 3767
Yasushi Hojo is an academic researcher from Saitama Medical University. The author has contributed to research in topics: Hippocampal formation & Hippocampus. The author has an hindex of 30, co-authored 57 publications receiving 3506 citations. Previous affiliations of Yasushi Hojo include University of Tokyo & University of Tsukuba.
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Journal ArticleDOI
Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017α and P450 aromatase localized in neurons
Yasushi Hojo,Taka-aki Hattori,Taihei Enami,A. Furukawa,Kumiko Suzuki,Hirotaka Ishii,Hideo Mukai,John H. Morrison,William G.M. Janssen,Shiro Kominami,Nobuhiro Harada,Tetsuya Kimoto,Suguru Kawato +12 more
TL;DR: Results imply that 17beta-estradiol is synthesized by P45017alpha and P450 aromatase localized in hippocampal neurons from endogenous cholesterol, and may be regulated by a glutamate-mediated synaptic communication that evokes Ca(2+) signals.
Journal ArticleDOI
Neurosteroid Synthesis by Cytochrome P450-Containing Systems Localized in the Rat Brain Hippocampal Neurons: N-Methyl-d-Aspartate and Calcium-Dependent Synthesis
Tetsuya Kimoto,Tomokazu Tsurugizawa,Yoichiro Ohta,Jun'ya Makino,Hiroomi Tamura,Yasushi Hojo,Norio Takata,Suguru Kawato +7 more
TL;DR: Observations imply that hippocampal neurons synthesize neurosteroids, which may be stimulated and regulated by glutamate-mediated synaptic communication.
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Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons.
Hideo Mukai,Tomokazu Tsurugizawa,Gen Murakami,Shiro Kominami,Hirotaka Ishii,Mari Ogiue-Ikeda,Norio Takata,Nobuaki Tanabe,A. Furukawa,Yasushi Hojo,Yuuki Ooishi,John H. Morrison,William G.M. Janssen,John A. Rose,Pierre Chambon,Shigeaki Kato,Shunsuke Izumi,Takeshi Yamazaki,Tetsuya Kimoto,Suguru Kawato +19 more
TL;DR: Two types of independent synaptic plasticity, long‐term depression and spinogenesis, were investigated, in response to 17β‐estradiol and agonists of estrogen receptors using hippocampal slices from adult male rats, and it was demonstrated that estradiol rapidly enhanced LTD not only in CA1 but also in CA3 and dentate gyrus.
Journal ArticleDOI
Estrogen synthesis in the brain—Role in synaptic plasticity and memory
Yasushi Hojo,Gen Murakami,Hideo Mukai,Shimpei Higo,Yusuke Hatanaka,Mari Ogiue-Ikeda,Hirotaka Ishii,Tetsuya Kimoto,Suguru Kawato +8 more
TL;DR: Estrogen modulates memory-related synaptic plasticity not only slowly but also rapidly in the hippocampus, and ERalpha, but not ERbeta, induces the same enhancement/suppression effects on both spinogenesis and LTD.
Journal ArticleDOI
Comparison between Hippocampus-Synthesized and Circulation-Derived Sex Steroids in the Hippocampus
Yasushi Hojo,Shimpei Higo,Hirotaka Ishii,Yuuki Ooishi,Hideo Mukai,Gen Murakami,Toshihiro Kominami,Tetsuya Kimoto,Seijiro Honma,Donald Poirier,Suguru Kawato +10 more
TL;DR: It is suggested that male hippocampal E2 synthesis pathway may be androstenedione --> T --> E2 or dehydroepiandrosterone --> and Frostenediol --> T ― E2 but not androstensione --> E1 --> E 2.