Yasuyuki Shima

TL;DR: Using genetic engineering in mice, approximately 20 Cre and inducible CreER knockin driver lines that reliably target major classes and lineages of GABAergic neurons are generated, thereby enabling a systematic and comprehensive analysis from cell fate specification, migration, and connectivity, to their functions in network dynamics and behavior.

TL;DR: It is suggested that cells acquire the P-D polarity by way of the Fz-dependent boundary localization of Fmi, which appears to be driven by an imbalance of the activity of Frizzled across the proximal/distal cell boundary.

TL;DR: Using cell-type-specific projection mapping with synaptic resolution, this work observed the convergence of separate sensory and basilar pontine pathways onto individual granule cells and mapped this convergence across cerebellar cortex, providing evidence that the convergent basilar Pontine pathways carry corollary discharges from upper body motor cortical areas.

TL;DR: This work shows that mammalian seven-pass transmembrane cadherins Celsr2 and CelsR3 are activated by their homophilic interactions and regulate neurite growth in an opposing manner, and that differences in the activities of the homologs results in opposite effects in neurites growth regulation.

TL;DR: Loss-of-function analysis using an RNAi system and organotypic brain slice cultures is performed to address the role of a mammalian Flamingo homolog, Celsr2, and discusses how CelsR2 may regulate dendritic maintenance and growth.