Yetkin Gök

TL;DR: The synthesis, crystal structure, characterization, and enzyme inhibition effects of the novel a series of 2-aminopyridine liganded Pd(II) N-heterocyclic carbene (NHC) complexes were examined and the inhibition effect of these derivatives on aldose reductase and α-glycosidase enzymes was studied.

TL;DR: This study contains novel a serie synthesis of N-heterocyclic carbene (NHC) precursors that 2-hydroxyethyl substituted that effectively inhibited the α-glycosidase, cytosolic carbonic anhydrase I and II isoforms, butyrylcholinesterase (BChE) and acetylcholinease (AChE).

TL;DR: Three series of imidazolidinium ligands substituted with 4‐vinylbenzyl, 2‐methyl‐1,4‐benzodioxane, and N‐propylphthalimide were synthesized and the inhibitory effects of the novel synthesized NHCs were compared to acetazolamide as a clinical CA isoenzymes inhibitor and tacrine as aclinical cholinergic enzymes inhibitor.

TL;DR: In this article, new Pd-N-heterocyclic carbene complexes have been prepared and employed for palladium-catalysed direct arylation of heteroaromatic derivatives by using aryl halides.