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Showing papers by "Yi Chen published in 1989"


Journal ArticleDOI
An Zhu1, Yi Chen1
TL;DR: The high-voltage wide-bore capillary zone electrophoresis of red blood cells was investigated and the reproducibility of the retention time (electrophoretic mobility) is excellent and the differentiation among various species is good.

29 citations


Journal ArticleDOI
TL;DR: In this article, a Copley fraction collector and a Disotest flow-through system were coupled to provide an automatic discrete sampling flowthrough dissolution system for use both in the open-loop and closed-loop mode.
Abstract: A Copley™ fraction collector and a Disotest™ flow-through system were coupled to provide an automatic discrete sampling flow-through dissolution system for use both in the “open-loop” and “closed-loop” mode. The system was used to investigate the release characteristics of adinazolam in sustained release formulations using a pH 1.2 simulated gastric fluid (without enzymes) dissolution medium (USP XXI). These experimental formulations are designed to provide relatively slow to rapid drug release. The dissolution effluent was analysed off-line by reverse phase HPLC to determine the adinazolam concentration at programmed timed intervals. The differential dissolution profiles produced when the system is used in the “open-loop” configuration are more discriminating in describing the release characteristics of the formulations according to the relative release rates than the “closed-loop” cumulative profiles. Using the characteristic dissolution time parameter from the Weibull function, a better correla...

11 citations