Showing papers by "Yi Chen published in 2006"
TL;DR: It is suggested that a predominant humoral cytokine profile occurs in the metastatic liver milieu and that a shift toward anti-inflammatory/immune-suppressive responses may promote HCC metastases.
761 citations
TL;DR: High-throughput analysis, using massively parallel signature sequencing (MPSS), of 230,000 tags from a DNase library generated from quiescent human CD4+ T cells identifies 14,190 clusters of sequences that group within close proximity to each other that represent valid DNase HS sites.
Abstract: A major goal in genomics is to understand how genes are regulated in different tissues, stages of development, diseases, and species. Mapping DNase I hypersensitive (HS) sites within nuclear chromatin is a powerful and well-established method of identifying many different types of regulatory elements, but in the past it has been limited to analysis of single loci. We have recently described a protocol to generate a genome-wide library of DNase HS sites. Here, we report high-throughput analysis, using massively parallel signature sequencing (MPSS), of 230,000 tags from a DNase library generated from quiescent human CD4+ T cells. Of the tags that uniquely map to the genome, we identified 14,190 clusters of sequences that group within close proximity to each other. By using a real-time PCR strategy, we determined that the majority of these clusters represent valid DNase HS sites. Approximately 80% of these DNase HS sites uniquely map within one or more annotated regions of the genome believed to contain regulatory elements, including regions 2 kb upstream of genes, CpG islands, and highly conserved sequences. Most DNase HS sites identified in CD4+ T cells are also HS in CD8+ T cells, B cells, hepatocytes, human umbilical vein endothelial cells (HUVECs), and HeLa cells. However, ∼10% of the DNase HS sites are lymphocyte specific, indicating that this procedure can identify gene regulatory elements that control cell type specificity. This strategy, which can be applied to any cell line or tissue, will enable a better understanding of how chromatin structure dictates cell function and fate.
513 citations
TL;DR: In this paper, the authors investigated the nonadiabatic dynamics of spinning black-hole binaries by using an analytical Hamiltonian completed with a radiation-reaction force, containing spin couplings, which matches the known rates of energy and angular-momentum losses on quasicircular orbits.
Abstract: We investigate the nonadiabatic dynamics of spinning black-hole binaries by using an analytical Hamiltonian completed with a radiation-reaction force, containing spin couplings, which matches the known rates of energy and angular-momentum losses on quasicircular orbits. We consider both a straightforward post-Newtonian-expanded Hamiltonian (including spin-dependent terms), and a version of the resummed post-Newtonian Hamiltonian defined by the effective one-body approach. We focus on the influence spin terms have on the dynamics and waveforms. We evaluate the energy and angular momentum released during the final stage of inspiral and plunge. For an equal-mass binary the energy released between 40 Hz and the frequency beyond which our analytical treatment becomes unreliable is found to be, when using the effective one-body dynamics, 0.6%M for antialigned maximally spinning black holes, 5%M for aligned maximally spinning black holes, and 1.8%M for nonspinning configurations. In confirmation of previous results, we find that, for all binaries considered, the dimensionless rotation parameter J/E{sup 2} is always smaller than unity at the end of the inspiral, so that a Kerr black hole can form right after the inspiral phase. By matching a quasinormal mode ring down to the last reliable stages of the plunge, we construct complete waveforms approximately describingmore » the gravitational-wave signal emitted by the entire process of coalescence of precessing binaries of spinning black holes.« less
177 citations
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TL;DR: The GEO-HF project as mentioned in this paper is a project to improve the sensitivity of the GEO detector by small sequential upgrades some of which will be tested in prototypes first, and the development, test and installation of these upgrades are named as the "Geo-HF Project."
Abstract: The GEO 600 gravitational wave detector uses advanced technologies including signal recycling and monolithic fused-silica suspensions to achieve a sensitivity close to the kilometre scale LIGO and VIRGO detectors. As soon as the design sensitivity of GEO 600 is reached, the detector will be operated as part of the worldwide network to acquire data of scientific interest. The limited infrastructure at the GEO site does not allow for a major upgrade of the detector. Hence the GEO collaboration decided to improve the sensitivity of the GEO detector by small sequential upgrades some of which will be tested in prototypes first. The development, test and installation of these upgrades are named 'The GEO-HF Project.' This paper describes the upgrades considered in the GEO-HF project as well as their scientific reasons. We will describe the changes in the GEO 600 infrastructure and the prototype work that is planned to support these upgrades. Finally, we will point to some laboratory research that identifies new technologies or optical configurations that might undergo a transition into detector subsystems within the GEO-HF project.
153 citations
TL;DR: The German/British project GEO600 achieved an instrumental duty cycle of 97% with a peak sensitivity of 7 × 10−22 Hz−1/2 at 1 kHz.
Abstract: Of all the large interferometric gravitational-wave detectors, the German/British project GEO600 is the only one which uses dual recycling. During the four weeks of the international S4 data-taking run it reached an instrumental duty cycle of 97% with a peak sensitivity of 7 × 10−22 Hz−1/2 at 1 kHz. This paper describes the status during S4 and improvements thereafter.
135 citations
TL;DR: Results support that myosin VI is critical in maintaining the malignant properties of the majority of human prostate cancers diagnosed today.
Abstract: Myosin VI is an actin motor that moves to the minus end of the polarized actin filament, a direction opposite to all other characterized myosins. Using expression microarrays, we identified myosin VI as one of the top genes that demonstrated cancer-specific overexpression in clinical prostate specimens. Protein expression of myosin VI was subsequently analyzed in arrayed prostate tissues from 240 patients. Notably, medium-grade prostate cancers demonstrated the most consistent cancer-specific myosin VI protein overexpression, whereas prostate cancers associated with more aggressive histological features continued to overexpress myosin VI but to a lesser extent. Myosin VI protein expression in cell lines positively correlated with the presence of androgen receptor. Small interference RNA-mediated myosin VI knockdown in the LNCaP human prostate cancer cell line resulted in impaired in vitro migration and soft-agar colony formation. Depletion of myosin VI expression was also accompanied by global gene expression changes reflective of attenuated tumorigenic potential, as marked by a nearly 10-fold induction of TXNIP (VDUP1), a tumor suppressor with decreased expression in prostate cancer specimens. These results support that myosin VI is critical in maintaining the malignant properties of the majority of human prostate cancers diagnosed today.
129 citations
TL;DR: In this paper, a reversal of the standard regiochemistry of the Skraup-Doebner-Von Miller quinoline synthesis was observed when anilines were condensed with gamma-aryl-beta,gamma-unsaturated alpha-ketoesters in refluxing TFA.
Abstract: A reversal of the standard regiochemistry of the Skraup-Doebner-Von Miller quinoline synthesis was observed when anilines were condensed with gamma-aryl-beta,gamma-unsaturated alpha-ketoesters in refluxing TFA. The reaction is proposed to involve 1,2-addition of the anilines to gamma-aryl-beta,gamma-unsaturated alpha-ketoesters to form Schiff's base adducts, followed by cyclization and oxidation. The products were unambiguously shown to the 2-carboxy-4-arylquinolines by spectroscopy and X-ray crystallographic analysis.
123 citations
TL;DR: This study shows that zinc, bismuth, manganese, or lanthanum species added to PEG solutions, in which PEG molecules are well dissolved in a coil state, convert the polymer coils to aggregate structures, which further aggregate into micrometer-sized M(n+)-PEG globules.
Abstract: We demonstrate the sphere organization of ZnO, Bi2S3, MnO2, and La(OH)3 nanorods directed by PEG linear polymer Our study shows that zinc, bismuth, manganese, or lanthanum species added to PEG solutions, in which PEG molecules are well dissolved in a coil state, convert the polymer coils to aggregate structures, which further aggregate into micrometer-sized Mn+−PEG globules The concentration of metallic species is higher in the globules than in bulk solutions The surfaces of the globules act as soft templates for the initial nucleation and thereafter the growth of the nanorods Finally, echinus-type assemblies of single-crystalline nanorods form by the metallic species hydrolyzing or reacting with deposition agents This approach opens the possibility of using polymers as soft templates to control the organization of nano building units into designed structures
104 citations
TL;DR: A synergism mechanism of C(5)N-six-membered-ring-based growth through surface diffusion and vapor-liquid-solid growth through bulk diffusion was accordingly deduced and schematically presented and could help understand the CN(x)()-nanotube-related experimental phenomena in the literature.
Abstract: A series of bamboo-like CNx nanotubes have been synthesized from pyridine precursor by chemical vapor deposition with bimetallic Fe−Co/γ-Al2O3 catalyst in the range of 550∼950 °C. An unusual predomination of pyridinic nitrogen over graphitic nitrogen has been observed for the CNx nanotubes with reaction temperature below 750 °C. The pyridinic nitrogen decreases and the graphitic nitrogen increases with rising reaction temperature. A synergism mechanism of C5N-six-membered-ring-based growth through surface diffusion and vapor−liquid−solid growth through bulk diffusion was accordingly deduced and schematically presented. This mechanism could not only explain our own experimental results, but also understand the CNx-nanotube-related experimental phenomena in the literature, as well as be in accordance with the basic principle of diffusion kinetics. A promising route to the challenging topic for synthesizing regularly arranged C5N or high-N-content CNx nanotubes has also been suggested.
100 citations
TL;DR: In this article, the authors proposed an experiment to extract ponderomotive squeezing from an interferometer with high circulating power and low mass mirrors, where optical resonances of the arm cavities are detuned from the laser frequency, creating a mechanical rigidity that dramatically suppresses displacement noises.
Abstract: We propose an experiment to extract ponderomotive squeezing from an interferometer with high circulating power and low mass mirrors. In this interferometer, optical resonances of the arm cavities are detuned from the laser frequency, creating a mechanical rigidity that dramatically suppresses displacement noises. After taking into account imperfection of optical elements, laser noise, and other technical noise consistent with existing laser and optical technologies and typical laboratory environments, we expect the output light from the interferometer to have measurable squeezing of 5 dB, with a frequency-independent squeeze angle for frequencies below 1 kHz. This squeeze source is well suited for injection into a gravitational-wave interferometer, leading to improved sensitivity from reduction in the quantum noise. Furthermore, this design provides an experimental test of quantum-limited radiation pressure effects, which have not previously been tested.
98 citations
TL;DR: It is reported that in the minimal supersymmetric standard model (mH+/-, tanbeta) plane the first exclusion regions with radiative and Yukawa coupling corrections are presented, allowing 95% C.L. upper limits to be placed on BR(t-->H+b) for different charged Higgs decay scenarios.
Abstract: We report the results of a search for a charged Higgs boson in the decays of top quarks produced in pp collisions at a center-of-mass energy of 1.96 TeV. We use a data sample corresponding to an integrated luminosity of 193 pb{sup -1} collected by the upgraded Collider Detector at Fermilab. No evidence for charged Higgs production is found, allowing 95% C.L. upper limits to be placed on BR(t{yields}H{sup +}b) for different charged Higgs decay scenarios. In addition, we present in the minimal supersymmetric standard model (m{sub H{sup {+-}}},tan{beta}) plane the first exclusion regions with radiative and Yukawa coupling corrections.
TL;DR: It is reported that oligomannurarate sulfate (JG3), a novel marine-derived oligosaccharide, acts as a heparanase inhibitor and should be considered as a promising candidate agent for cancer therapy.
Abstract: Inhibitors of tumor angiogenesis and metastasis are increasingly emerging as promising agents for cancer therapy. Recently, heparanase inhibitors have offered a new avenue for such work because heparanase is thought to be critically involved in the metastatic and angiogenic potentials of tumor cells. Here, we report that oligomannurarate sulfate (JG3), a novel marine-derived oligosaccharide, acts as a heparanase inhibitor. Our results revealed that JG3 significantly inhibited tumor angiogenesis and metastasis, both in vitro and in vivo, by combating heparanase activity via binding to the KKDC and QPLK domains of the heparanase molecule. The JG3-heparanase interaction was competitively inhibited by low molecular weight heparin (4,000 Da) but not by other glycosaminoglycans. In addition, JG3 abolished heparanase-driven invasion, inhibited the release of heparan sulfate-sequestered basic fibroblast growth factor (bFGF) from the extracellular matrix, and repressed subsequent angiogenesis. Moreover, JG3 inactivated bFGF-induced bFGF receptor and extracellular signal-regulated kinase 1/2 phosphorylation and blocked bFGF-triggered angiogenic events by directly binding to bFGF. Thus, JG3 seems to inhibit both major heparanase activities by simultaneously acting as a substrate mimetic and as a competitive inhibitor of heparan sulfate. These findings suggest that JG3 should be considered as a promising candidate agent for cancer therapy.
TL;DR: In this paper, a search for gravitational waves from binary black hole inspirals in the data from the second science run of the LIGO interferometers was reported. But no events that could be identified as gravitational waves in the 385.6 hours of data that they searched.
Abstract: We report on a search for gravitational waves from binary black hole inspirals in the data from the second science run of the LIGO interferometers. The search focused on binary systems with component masses between 3 and 20M⊙. Optimally oriented binaries with distances up to 1 Mpc could be detected with efficiency of at least 90%. We found no events that could be identified as gravitational waves in the 385.6 hours of data that we searched.
TL;DR: Mechanistic investigation on spherical assembly of the unique one-dimensional ZnO nanorods, solid nanocones, or hollow prisms with the closed -c end, directed by poly ethylene glycol (PEG) with different molecular weights, has been carried out using spectroscopic methods.
Abstract: Mechanistic investigation on spherical assembly of the unique one-dimensional ZnO nanorods, solid nanocones, or hollow prisms with the closed −c end, directed by poly ethylene glycol (PEG) with different molecular weights, has been carried out using spectroscopic methods. The single crystalline ZnO nanoprisms, hollow along the c axis but closed at the −c end, aggregate to urchin-type globules in the microscale when PEG 2000 is used as directing reagent, while spherical aggregates of single crystalline ZnO nanocones are obtained under the direction of PEG 200. Studies reveal that both the PEG molecules aggregate to globules by interacting with zinc species in suitable solvents and englobe the zinc species. By the short time of ultrasonic pretreatment on the solution, a kind of flagellum structure is induced around the globules, in long tubular shapes for PEG 2000 but as shorter wedges for PEG 200. The globules with flagellums are templates for the assembly of the ZnO nanotubes or ZnO nanocones in the hydro...
TL;DR: In this paper, the CDF II detector at Fermilab has been used to measure the top quark mass of the hadronically decaying $W$ boson.
Abstract: This article presents a measurement of the top quark mass using the CDF II detector at Fermilab. Colliding beams of protons and antiprotons at Fermilab's Tevatron ($\sqrt{s}=1.96\text{ }\text{ }\mathrm{TeV}$) produce top/antitop pairs, which decay to ${W}^{+}{W}^{\ensuremath{-}}b\overline{b}$; events are selected where one $W$ decays to hadrons and the other $W$ decays to either $e$ or $\ensuremath{\mu}$ plus a neutrino. The data sample corresponds to an integrated luminosity of approximately $318\text{ }\text{ }{\mathrm{pb}}^{\ensuremath{-}1}$. A total of 165 $t\overline{t}$ events are separated into four subsamples based on jet transverse energy thresholds and the number of $b$ jets identified by reconstructing a displaced vertex. In each event, the reconstructed top quark invariant mass is determined by minimizing a ${\ensuremath{\chi}}^{2}$ for the overconstrained kinematic system. At the same time, the mass of the hadronically decaying $W$ boson is measured in the same event sample. The observed $W$ boson mass provides an in situ improvement in the determination of the hadronic jet energy scale. A simultaneous likelihood fit of the reconstructed top quark masses and the $W$ boson invariant masses in the data sample to distributions from simulated signal and background events gives a top quark mass of ${173.5}_{\ensuremath{-}3.8}^{+3.9}\text{ }\text{ }\mathrm{GeV}/{c}^{2}$.
TL;DR: A growing body of new evidence suggests that cell death regulators also have ‘day jobs’ in healthy cells and caspases, mitochondrial fission proteins and pro-death Bcl-2 family proteins appear to have normal cellular functions that promote cell survival.
Abstract: At least in mammals, we have some understanding of how caspases facilitate mitochondria-mediated cell death, but the biochemical mechanisms by which other factors promote or inhibit programmed cell death are not understood. Moreover, most of these factors are only studied after treating cells with a death stimulus. A growing body of new evidence suggests that cell death regulators also have 'day jobs' in healthy cells. Even caspases, mitochondrial fission proteins and pro-death Bcl-2 family proteins appear to have normal cellular functions that promote cell survival. Here, we review some of the supporting evidence and stretch beyond the evidence to seek an understanding of the remaining questions.
TL;DR: It is shown that Hec1 directly interacts with human ZW10 interacting protein (Zwint-1), a binding partner of Zeste White 10 (ZW10) that is required for chromosome motility and spindle checkpoint control and faithful chromosome segregation.
Abstract: Faithful chromosome segregation is essential for maintaining the genomic integrity, which requires coordination among chromosomes, kinetochores, centrosomes and spindles during mitosis. Previously, we discovered a novel coiled-coil protein, highly expressed in cancer 1 (Hec1), which is indispensable for this process. However, the precise underlying mechanism remains unclear. Here, we show that Hec1 directly interacts with human ZW10 interacting protein (Zwint-1), a binding partner of Zeste White 10 (ZW10) that is required for chromosome motility and spindle checkpoint control. In mitotic cells, Hec1 transiently forms complexes with Zwint-1 and ZW10 in a temporal and spatial manner. Although the three proteins have variable cell cycle-dependent expression profiles, they can only be co-immunoprecipitated during M phase. Immunofluorescent study showed that Hec1 and Zwint-1 co-localize at kinetochores beginning at prophase and that ZW10 joins them later at prometaphase. Depletion of Hec1 impairs the recruitment of both Zwint-1 and ZW10 to kinetochores, while depletion of Zwint-1 abrogates the kinetochore localization of ZW10 but not Hec1. The results suggest that the localization of Hec1 at kinetochores is required for the sequential recruitment of Zwint-1 and ZW10. Disrupting this recruitment by inhibiting the expression of Hec1 or Zwint-1 causes chromosome missegregation, spindle checkpoint failure, and eventually cell death upon cytokinesis. Taken together, these results, at least in part, provide a molecular basis to explain how Hec1 plays a crucial role for spindle checkpoint control and faithful chromosome segregation.
TL;DR: Functional evidence is provided that oncogene AF1Q may be a novel mediator of metastasis promotion in human breast cancer through regulation of the MMP pathway and RhoC expression.
TL;DR: The results showed that the monolithic column could realize deproteinization and trace drug enrichment simultaneously in the HSA solution and human plasma, which provided a simple, cheap, effective and friendly to environment method for assaying drugs in the blood.
TL;DR: Chen et al. as mentioned in this paper investigated the dispersion of copper oxide in CuO/TiO2 samples prepared by one and double-step impregnations and the NO+CO activities of CuO and TiO2.
Abstract: X-ray diffraction (XRD), temperature-programmed reduction (TPR) and X-ray photoelectron spectroscopy (XPS) were employed to investigate the dispersion of copper oxide in CuO/TiO2 samples prepared by one and double-step impregnations and the NO + CO activities of CuO/TiO2 samples were also tested. The results indicate that the dispersion capacity of copper oxide in CuO/TiO2 samples with one-step impregnation and double impregnations are about 0.52 and 0.98 mmol/100 m2 TiO2, respectively, which should be related to the shielding effect of accompanying NO3− anions during the impregnations. Therefore, the dispersion capacity of copper oxide on anatase with double impregnations could approach to 1.16 mmol/100 m2 TiO2, i.e. a value corresponding to the density of vacant sites on the (0 0 1) surface of TiO2. The NO + CO activities of CuO/TiO2 samples suggest that dispersed copper oxide species in these catalysts is the mainly active species and the increasing amount of dispersed copper oxide would enhance their activities. It seems to suggest that, for the supported catalysts, double or multiple impregnations would result in better activity than those prepared by one-step impregnation. In addition, the coordination environment of the dispersed copper oxide species existed on the anatase surface has been discussed by the incorporation model [Y. Chen, L.F. Zhang, Catal. Lett. 12 (1992) 51].
TL;DR: In this article, the authors determined that the gravitational waveform corrections resulting from these changes are too small to affect the main quantitative results of this paper and pointed out that the previously unknown value of the parameter \u0005̂, which enters the Gravitational wave flux at the 3PN order, has been determined to be 1039=4620.
Abstract: The changes affect the 2PN and 3PN coefficients that multiply M! 5=3 and M! 7=3, respectively. By means of order-ofmagnitude arguments and of limited numerical tests, we have determined that the gravitational waveform corrections resulting from these changes are too small to affect the main quantitative results of this paper. In addition, we point out that the previously unknown value of the parameter \u0005̂, which enters the gravitational wave flux at the 3PN order, has been determined to be 1039=4620 [4]. Last, all the spins (S1, S2, and Seff) that appear in Eq. (11) should be divided by M2.
TL;DR: In this article, the authors search Z{prime} bosons in dielectron events produced in p{bar p} collisions at {radical}s = 1.96 TeV, using a 0.45 fb{sup -1} dataset accumulated with the CDF II detector at the Fermilab Tevatron.
Abstract: The authors search Z{prime} bosons in dielectron events produced in p{bar p} collisions at {radical}s = 1.96 TeV, using a 0.45 fb{sup -1} dataset accumulated with the CDF II detector at the Fermilab Tevatron. To identify the Z{prime} {yields} e{sup +}e{sup -} signal, both the dielectron invariant mass distribution and the angular distribution of the electron pair are used. No evidence of a signal is found, and 95% confidence level lower limits are set on the Z{prime} mass for several models. Limits are also placed on the mass and gauge coupling of a generic Z{prime}, as well as on the contact interaction mass scales for different helicity structure scenarios.
TL;DR: The results showed FAS protein expression and basal activity levels were higher in HepG2 cells than in the other two HCC cell lines, and a clear correlation between p38 MAPK activation triggered by C75 and the induction of cell cycle arrests in all three HCC cells.
Abstract: C75, a well-known fatty acid synthase (FAS) inhibitor, has been shown to possess potent anti-cancer activity in vitro and in vivo. In this study, we reveal that C75 is a cell cycle arrest inducer and explore the potential mechanisms for this effect in hepatocellular carcinoma (HCC) cell lines with abundant FAS expression: HepG2 and SMMC7721 cells with wt-p53, and Hep3B cells with null p53. The results showed FAS protein expression and basal activity levels were higher in HepG2 cells than in the other two HCC cell lines. Treatment with C75 inhibited FAS activity within 30 min of administration and induced G(2) phase arrest accompanied by p53 overexpression in HepG2 and SMMC7721 cells. By contrast, C75 triggered G(1) phase arrest in Hep3B cells, and RNA interference targeting p53 did not attenuate C75-induced G(2) arrest in HepG2 cells. Similarly, p53 overexpression via p53 plasmid transfection did not affect C75-induced G(1) phase arrest in Hep3B cells. However, we observed a clear correlation between p38 MAPK activation triggered by C75 and the induction of cell cycle arrest in all three HCC cells. Furthermore, treatment with the p38 MAPK inhibitor SB203580 reduced p38 MAPK activity and cell cycle arrest, and also partially restored cyclin A, cyclin B1, cyclin D1 and p21 protein levels. Collectively, it was p38 MAPK but not p53 involved in C75-mediated tumor cell growth arrest in HCC cells.
TL;DR: The analytical method fulfills all the standard requirements of linearity, accuracy and precision, therefore, it is suitable for purification and routine quantification of stachyose in Chinese artichoke.
TL;DR: Polycrystalline hollow AlN nanospheres with diameters ranging from 20 to 200 nm and shell thickness of about 10 nm were successfully synthesized through the reaction of irregular Al nanopowder with a CH4-NH3 mixture at around 1000 °C by the self-templated method.
Abstract: Polycrystalline hollow AlN nanospheres with diameters ranging from 20 to 200 nm and shell thickness of about 10 nm were successfully synthesized through the reaction of irregular Al nanopowder with a CH4–NH3 mixture at around 1000 °C by the self-templated method. The products were well characterized by X-ray diffraction, high-resolution transmission electron microscopy, Raman spectroscopy and photoluminescence measurements. The photoluminescence properties of the hollow AlN nanospheres showed the routine blue emissions for AlN nanoparticles as well as an unusual green emission at around 533 nm, indicating the potential for luminescent devices. The synthesis mechanism was reasonably speculated and further supported by the similar synthesis of hollow AlN nanospheres from regular Al particles.
TL;DR: Investigation of patterns of gene expression in placental samples from patients with preeclampsia, persistent bilateral uterine artery notching, and normal controls found downregulation of RELA and calmodulin 2 might represent an attempt by the placenta to compensate for elevations in intracellular calcium.
Abstract: The aim of this study was to investigate patterns of gene expression in placental samples from patients with preeclampsia (PE), persistent bilateral uterine artery notching (without PE), and normal controls. This study included placental tissue from nine women with PE, seven with uncomplicated pregnancies and five with bilateral uterine artery notching in Doppler velocimetry tracings. Human cDNA microarrays with 6500 transcripts/genes were used and the results verified with real-time PCR and in-situ hybridization. Multidimensional scaling method and random permutation technique demonstrated significant differences among the three groups examined. Within the 6.5K arrays, 6198 elements were unique cDNA clones representing 5952 unique UniGenes and 5695 unique LocusLinks. Multidimensional scaling plots showed 5000 genes that met our quality criteria; among these, 366 genes were significantly different in at least one comparison. Differences in three genes of interest were confirmed with real-time PCR and in-situ hybridization; acid phosphatase 5 was shown to be overexpressed in PE samples and calmodulin 2 and v-rel reticuloendotheliosis viral oncogene homolog A (RELA) were downregulated in PE and uterine artery notch placentas. In conclusion downregulation of RELA and calmodulin 2 might represent an attempt by the placenta to compensate for elevations in intracellular calcium, possibly caused by hypoxia and/or apoptosis, in both pregnancies with uterine artery notching and preeclampsia.
TL;DR: In this paper, the authors present a search for neutral supersymmetric Higgs bosons decaying to tau pairs produced in pp collisions at square root of s = 1.96 TeV.
Abstract: We present a search for neutral supersymmetric Higgs bosons decaying to tau pairs produced in pp collisions at square root of s = 1.96 TeV. The data, corresponding to 310 pb(-1) integrated luminosity, were collected with the Collider Detector at Fermilab in run II of the Tevatron. No significant excess above the standard model backgrounds is observed. We set exclusion limits on the production cross section times branching fraction to tau pairs for Higgs boson masses in the range from 90 to 250 GeV/c2.
TL;DR: A series of new anthrapyrazoles derived from emodin by attaching various cationic alkyl amino side chains onto a pyrazole ring which had been incorporated into the anthraquinone chromophore had significantly higher DNA binding affinity based on interaction with calf thymus DNA and much more potent cytotoxicity against different tumor cells.
TL;DR: This first application of a matrix-element technique to tt --> bl+ nu(l)bl'- nu'+ nu'(l') decays gives the most precise single measurement of M(t) in dilepton events.
Abstract: We report a measurement of the top quark mass using events collected by the CDF II Detector from p{bar p} collisions at {radical}s = 1.96 TeV at the Fermilab Tevatron. We calculate a likelihood function for the top mass in events that are consistent with t{bar t} {yields} {bar b}{ell}{sup -}{bar {nu}}{sub {ell}}b{ell}{prime}{sup +}{nu}{sub {ell}}{prime} decays. The likelihood is formed as the convolution of the leading-order matrix element and detector resolution functions. The joint likelihood is the product of likelihoods for each of 33 events collected in 340 pb{sup -1} of integrated luminosity, yielding a top quark mass M{sub t} = 165.2 {+-} 6.1(stat.) {+-} 3.4(syst.) GeV/c{sup 2}. This first application of a matrix-element technique to t{bar t} {yields} b{ell}{sup +}{nu}{sub {ell}}{bar b}{ell}{prime}{sup -}{bar {nu}}{sub {ell}}, decays gives the most precise single measurement of M{sub t} in dilepton events. Combined with other CDF Run II measurements using dilepton events, we measure M{sub t} = 167.9 {+-} 5.2(stat.) {+-} 3.7(syst.) GeV/c{sup 2}.