Yi Chen

Bio: Yi Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Large Hadron Collider & Medicine. The author has an hindex of 217, co-authored 4342 publications receiving 293080 citations. Previous affiliations of Yi Chen include Rochester Institute of Technology & National Institutes of Health.

Upper Limit map of a background of gravitational waves

Abstract: We searched for an anisotropic background of gravitational waves using data from the LIGO S4 science run and a method that is optimized for point sources. This is appropriate if, for example, the gravitational wave background is dominated by a small number of distinct astrophysical sources. No signal was seen. Upper limit maps were produced assuming two different power laws for the source strain power spectrum. For an f^(−3) power law and using the50 Hz to 1.8 kHz band the upper limits on the source strain power spectrum vary between 1.2×10^(−48) Hz^(−1) (100 Hz/f)^3 and 1.2×10^(−47) Hz^(−1) (100 Hz/f)^3, depending on the position in the sky. Similarly, in the case of constant strain power spectrum, the upper limits vary between 8.5×10−49 Hz−1 and 6.1×10^(−48) Hz^(−1). As a side product a limit on an isotropic background of gravitational waves was also obtained. All limits are at the 90% confidence level. Finally, as an application, we focused on the direction of Sco-X1, the brightest low-mass x-ray binary. We compare the upper limit on strain amplitude obtained by this method to expectations based on the x-ray flux from Sco-X1.

Measurements of Higgs boson properties in the diphoton decay channel in proton-proton collisions at √s=13 TeV

Abstract: Measurements of Higgs boson properties in the H → γγ decay channel are reported. The analysis is based on data collected by the CMS experiment in proton-proton collisions at $ \sqrt{s}=13 $ TeV during the 2016 LHC running period, corresponding to an integrated luminosity of 35.9 fb$^{−1}$. Allowing the Higgs mass to float, the measurement yields a signal strength relative to the standard model prediction of 1.18$_{− 0.14}^{+ 0.17}$ = 1.18$_{− 0.11}^{+ 0.12}$ (stat)$_{− 0.07}^{+ 0.09}$ (syst)$_{− 0.06}^{+ 0.07}$ (theo), which is largely insensitive to the exact Higgs mass around 125 GeV. Signal strengths associated with the different Higgs boson production mechanisms, couplings to bosons and fermions, and effective couplings to photons and gluons are also measured.

Studies of jet mass in dijet and W/Z + jet events

Abstract: Invariant mass spectra for jets reconstructed using the anti-kt and Cambridge-Aachen algorithms are studied for different jet "grooming" techniques in data corresponding to an integrated luminosity of 5 inverse femtobarns, recorded with the CMS detector in proton-proton collisions at the LHC at a center-of-mass energy of 7 TeV. Leading-order QCD predictions for inclusive dijet and W/Z+jet production combined with parton-shower Monte Carlo models are found to agree overall with the data, and the agreement improves with the implementation of jet grooming methods used to distinguish merged jets of large transverse momentum from softer QCD gluon radiation.

Search for a light sterile neutrino at Daya Bay.

Abstract: A search for light sterile neutrino mixing was performed with the first 217 days of data from the Daya Bay Reactor Antineutrino Experiment. The experiment's unique configuration of multiple baselines from six 2.9 GW(th) nuclear reactors to six antineutrino detectors deployed in two near (effective baselines 512 m and 561 m) and one far (1579 m) underground experimental halls makes it possible to test for oscillations to a fourth (sterile) neutrino in the 10(-3) eV(2)<|Δm(41)(2) |< 0.3 eV(2) range. The relative spectral distortion due to the disappearance of electron antineutrinos was found to be consistent with that of the three-flavor oscillation model. The derived limits on sin(2) 2θ(14) cover the 10(-3) eV(2) ≲ |Δm(41)(2)| ≲ 0.1 eV(2) region, which was largely unexplored.

Study of (W/Z)H production and Higgs boson couplings using H→ W W∗ decays with the ATLAS detector

Abstract: A search for Higgs boson production in association with a W or Z boson, in the H -> WW* decay channel, is performed with a data sample collected with the ATLAS detector at the LHC in proton-proton collisions at centre-of-mass energies root s = 7 TeV and 8TeV, corresponding to integrated luminosities of 4.5 fb(-1) and 20.3 fb(-1), respectively. The W H production mode is studied in two-lepton and three-lepton final states, while twolepton and four-lepton final states are used to search for the ZH production mode. The observed significance, for the combined WH and ZH production, is 2.5 standard deviations while a significance of 0.9 standard deviations is expected in the Standard Model Higgs boson hypothesis. The ratio of the combined W H and Z H signal yield to the Standard Model expectation, mu(VH), is found to be mu(VH) = 3.0(-1.1)(+1.3)(stat.)(-0.7)(+1.0) (sys.) for the Higgs boson mass of 125.36 GeV. The WH and ZH production modes are also combined with the gluon fusion and vector boson fusion production modes studied in the H -> WW* -> l nu l nu decay channel, resulting in an overall observed significance of 6.5 standard deviations and mu F-gg+VBF+VH = 1.16(-0.15)(+0.16)(stat.)(-0.15)(+0.18)(sys.). The results are interpreted in terms of scaling factors of the Higgs boson couplings to vector bosons (kappa(V)) and fermions (kappa(F)); the combined results are: vertical bar kappa(V)vertical bar = 1.06(-0.10)(+0.10), vertical bar kappa(F)vertical bar = 0.85(-0.20)(+0.26)

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

KEGG: Kyoto Encyclopedia of Genes and Genomes

Abstract: Kyoto Encyclopedia of Genes and Genomes (KEGG) is a knowledge base for systematic analysis of gene functions in terms of the networks of genes and molecules. The major component of KEGG is the PATHWAY database that consists of graphical diagrams of biochemical pathways including most of the known metabolic pathways and some of the known regulatory pathways. The pathway information is also represented by the ortholog group tables summarizing orthologous and paralogous gene groups among different organisms. KEGG maintains the GENES database for the gene catalogs of all organisms with complete genomes and selected organisms with partial genomes, which are continuously re-annotated, as well as the LIGAND database for chemical compounds and enzymes. Each gene catalog is associated with the graphical genome map for chromosomal locations that is represented by Java applet. In addition to the data collection efforts, KEGG develops and provides various computational tools, such as for reconstructing biochemical pathways from the complete genome sequence and for predicting gene regulatory networks from the gene expression profiles. The KEGG databases are daily updated and made freely available (http://www.genome.ad.jp/kegg/).

limma powers differential expression analyses for RNA-sequencing and microarray studies

Abstract: limma is an R/Bioconductor software package that provides an integrated solution for analysing data from gene expression experiments. It contains rich features for handling complex experimental designs and for information borrowing to overcome the problem of small sample sizes. Over the past decade, limma has been a popular choice for gene discovery through differential expression analyses of microarray and high-throughput PCR data. The package contains particularly strong facilities for reading, normalizing and exploring such data. Recently, the capabilities of limma have been significantly expanded in two important directions. First, the package can now perform both differential expression and differential splicing analyses of RNA sequencing (RNA-seq) data. All the downstream analysis tools previously restricted to microarray data are now available for RNA-seq as well. These capabilities allow users to analyse both RNA-seq and microarray data with very similar pipelines. Second, the package is now able to go past the traditional gene-wise expression analyses in a variety of ways, analysing expression profiles in terms of co-regulated sets of genes or in terms of higher-order expression signatures. This provides enhanced possibilities for biological interpretation of gene expression differences. This article reviews the philosophy and design of the limma package, summarizing both new and historical features, with an emphasis on recent enhancements and features that have not been previously described.

Atherosclerosis — An Inflammatory Disease

Abstract: Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the principal risk factors for atherosclerosis,1 the process of atherogenesis has been considered by many to consist largely of the accumulation of lipids within the artery wall; however, it is much more than that. Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations,2,3 cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.4,5 In fact, the lesions of atherosclerosis represent . . .