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Yi Chen

Bio: Yi Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Large Hadron Collider & Medicine. The author has an hindex of 217, co-authored 4342 publications receiving 293080 citations. Previous affiliations of Yi Chen include Rochester Institute of Technology & National Institutes of Health.


Papers
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Journal ArticleDOI
TL;DR: In this paper, a search is performed for a heavy Majorana neutrino (N), produced in leptonic decay of a W boson propagator and decaying into a W-broson and a lepton, with the CMS detector at the LHC.
Abstract: A search is performed for a heavy Majorana neutrino (N), produced in leptonic decay of a W boson propagator and decaying into a W boson and a lepton, with the CMS detector at the LHC. The signature used in this search consists of two same-sign leptons, in any flavor combination of electrons and muons, and at least one jet. The data were collected during 2016 in proton-proton collisions at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1). The results are found to be consistent with the expected standard model background. Upper limits are set in the mass range between 20 and 1600 GeV in the context of a Type-I seesaw mechanism, on |V-eN|(2), |V-N|(2), and |VeNV *|(2)/(|V-eN|(2)+|V-N|(2)), where V-N is the matrix element describing the mixing of N with the standard model neutrino of flavor = e, . For N masses between 20 and 1600 GeV, the upper limits on |V-N|(2) range between 2.3 x 10(-5) and unity. These are the most restrictive direct limits for heavy Majorana neutrino masses above 430 GeV.

87 citations

Journal ArticleDOI
S. Chatrchyan1, Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1  +2236 moreInstitutions (172)
TL;DR: In this paper, a search for narrow resonances and quantum black holes is performed in inclusive and b-tagged dijet mass spectra measured with the CMS detector at the LHC.
Abstract: A search for narrow resonances and quantum black holes is performed in inclusive and b-tagged dijet mass spectra measured with the CMS detector at the LHC. The data set corresponds to 5 inverse femtobarns of integrated luminosity collected in pp collisions at sqrt(s) = 7 TeV. No narrow resonances or quantum black holes are observed. Model-independent upper limits at the 95% confidence level are obtained on the product of the cross section, branching fraction into dijets, and acceptance for three scenarios: decay into quark-quark, quark-gluon, and gluon-gluon pairs. Specific lower limits are set on the mass of string resonances (4.31 TeV), excited quarks (3.32 TeV), axi-gluons and colorons (3.36 TeV), scalar color-octet resonances (2.07 TeV), E(6) diquarks (3.75 TeV), and on the masses of W' (1.92 TeV) and Z' (1.47 TeV) bosons. The limits on the minimum mass of quantum black holes range from 4 to 5.3 TeV. In addition, b-quark tagging is applied to the two leading jets and upper limits are set on the production of narrow dijet resonances in a model-independent fashion as a function of the branching fraction to b-jet pairs.

87 citations

Journal ArticleDOI
TL;DR: In this article, a search for microscopic black holes in pp collisions at a center-of-mass energy of 7 TeV is presented, which corresponds to an integrated luminosity of 4.7 inverse femtobarns recorded by the LHC in 2011.
Abstract: A search for microscopic black holes in pp collisions at a center-of-mass energy of 7 TeV is presented. The data sample corresponds to an integrated luminosity of 4.7 inverse femtobarns recorded by the CMS experiment at the LHC in 2011. Events with large total transverse energy have been analyzed for the presence of multiple energetic jets, leptons, and photons, which are typical signals of evaporating semiclassical and quantum black holes, and string balls. Agreement with the expected standard model backgrounds, which are dominated by QCD multijet production, has been observed for various combined multiplicities of jets and other reconstructed objects in the final state. Model-independent limits are set on new physics processes producing high-multiplicity, energetic final states. In addition, new model-specific indicative limits are set excluding semiclassical and quantum black holes with masses below 3.8 to 5.3 TeV and string balls with masses below 4.6 to 4.8 TeV. The analysis has a substantially increased sensitivity compared to previous searches.

87 citations

Journal ArticleDOI
Georges Aad1, T. Abajyan2, Brad Abbott3, Jalal Abdallah  +2890 moreInstitutions (177)
TL;DR: In this paper, a study of WZ production in proton-proton collisions at 7 TeV is presented using data corresponding to an integrated luminosity of 4.6 fb^-1 collected with the ATLAS detector at the Large Hadron Collider in 2011.
Abstract: A study of WZ production in proton-proton collisions at sqrt(s) = 7 TeV is presented using data corresponding to an integrated luminosity of 4.6 fb^-1 collected with the ATLAS detector at the Large Hadron Collider in 2011. In total, 317 candidates, with a background expectation of 68+/-10 events, are observed in double-leptonic decay final states with electrons, muons and missing transverse momentum. The total cross-section is determined to be sigma_WZ(tot) = 19.0+1.4/-1.3(stat.)+/-0.9(cyst.)+/-0.4(lump.) pb, consistent with the Standard Model expectation of 17.6+1.1/-1.0 pb. Limits on anomalous triple gauge boson couplings are derived using the transverse momentum spectrum of Z bosons in the selected events. The cross-section is also presented as a function of Z boson transverse momentum and diboson invariant mass.

87 citations

Journal ArticleDOI
B. P. Abbott1, R. Abbott1, Rana X. Adhikari1, P. Ajith2  +508 moreInstitutions (56)
TL;DR: In this paper, an all-sky search for periodic gravitational waves from sources such as deformed and rapidly spinning neutron stars was performed using 840 hours of data from 66 days of the fifth LIGO science run (S5).
Abstract: This paper reports on an all-sky search for periodic gravitational waves from sources such as deformed isolated rapidly spinning neutron stars. The analysis uses 840 hours of data from 66 days of the fifth LIGO science run (S5). The data were searched for quasimonochromatic waves with frequencies f in the range from 50 to 1500 Hz, with a linear frequency drift _ƒ (measured at the solar system barycenter) in the range -ƒ/T < ƒ_ < 0:1ƒ/T, for a minimum spin-down age T of 1000 years for signals below 400 Hz and 8000 years above 400 Hz. The main computational work of the search was distributed over approximately 100 000 computers volunteered by the general public. This large computing power allowed the use of a relatively long coherent integration time of 30 hours while searching a large parameter space. This search extends Einstein@Home’s previous search in LIGO S4 data to about 3 times better sensitivity. No statistically significant signals were found. In the 125–225 Hz band, more than 90% of sources with dimensionless gravitational-wave strain tensor amplitude greater than 3 X 10^(-24) would have been detected.

87 citations


Cited by
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Journal ArticleDOI

[...]

08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

Journal ArticleDOI
TL;DR: The Kyoto Encyclopedia of Genes and Genomes (KEGG) as discussed by the authors is a knowledge base for systematic analysis of gene functions in terms of the networks of genes and molecules.
Abstract: Kyoto Encyclopedia of Genes and Genomes (KEGG) is a knowledge base for systematic analysis of gene functions in terms of the networks of genes and molecules. The major component of KEGG is the PATHWAY database that consists of graphical diagrams of biochemical pathways including most of the known metabolic pathways and some of the known regulatory pathways. The pathway information is also represented by the ortholog group tables summarizing orthologous and paralogous gene groups among different organisms. KEGG maintains the GENES database for the gene catalogs of all organisms with complete genomes and selected organisms with partial genomes, which are continuously re-annotated, as well as the LIGAND database for chemical compounds and enzymes. Each gene catalog is associated with the graphical genome map for chromosomal locations that is represented by Java applet. In addition to the data collection efforts, KEGG develops and provides various computational tools, such as for reconstructing biochemical pathways from the complete genome sequence and for predicting gene regulatory networks from the gene expression profiles. The KEGG databases are daily updated and made freely available (http://www.genome.ad.jp/kegg/).

24,024 citations

Journal ArticleDOI
TL;DR: The philosophy and design of the limma package is reviewed, summarizing both new and historical features, with an emphasis on recent enhancements and features that have not been previously described.
Abstract: limma is an R/Bioconductor software package that provides an integrated solution for analysing data from gene expression experiments. It contains rich features for handling complex experimental designs and for information borrowing to overcome the problem of small sample sizes. Over the past decade, limma has been a popular choice for gene discovery through differential expression analyses of microarray and high-throughput PCR data. The package contains particularly strong facilities for reading, normalizing and exploring such data. Recently, the capabilities of limma have been significantly expanded in two important directions. First, the package can now perform both differential expression and differential splicing analyses of RNA sequencing (RNA-seq) data. All the downstream analysis tools previously restricted to microarray data are now available for RNA-seq as well. These capabilities allow users to analyse both RNA-seq and microarray data with very similar pipelines. Second, the package is now able to go past the traditional gene-wise expression analyses in a variety of ways, analysing expression profiles in terms of co-regulated sets of genes or in terms of higher-order expression signatures. This provides enhanced possibilities for biological interpretation of gene expression differences. This article reviews the philosophy and design of the limma package, summarizing both new and historical features, with an emphasis on recent enhancements and features that have not been previously described.

22,147 citations

Journal ArticleDOI
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Abstract: Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the principal risk factors for atherosclerosis,1 the process of atherogenesis has been considered by many to consist largely of the accumulation of lipids within the artery wall; however, it is much more than that. Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations,2,3 cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.4,5 In fact, the lesions of atherosclerosis represent . . .

19,881 citations