Y
Yi Han
Researcher at University of Southern California
Publications - 17
Citations - 528
Yi Han is an academic researcher from University of Southern California. The author has contributed to research in topics: Genome-wide association study & Odds ratio. The author has an hindex of 9, co-authored 16 publications receiving 285 citations. Previous affiliations of Yi Han include University Health System & National University of Singapore.
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Journal ArticleDOI
Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk
Xinmin S. Li,Zeneng Wang,Tomas Cajka,Jennifer A. Buffa,Ina Nemet,Alex G Hurd,Xiaodong Gu,Sarah M. Skye,Adam B. Roberts,Yuping Wu,Lin Li,Christopher J. Shahen,Matthew A. Wagner,Jaana Hartiala,Robert L. Kerby,Kymberleigh A. Romano,Yi Han,Slayman Obeid,Thomas F. Lüscher,Thomas F. Lüscher,Hooman Allayee,Federico E. Rey,Joseph A. DiDonato,Oliver Fiehn,Oliver Fiehn,W.H. Wilson Tang,W.H. Wilson Tang,Stanley L. Hazen,Stanley L. Hazen +28 more
TL;DR: TML is identified as a strong predictor of incident CVD risks in subjects and to serve as a dietary precursor for gut microbiota-dependent generation of TMAO; however, TML does not appear to be a major microbial source for T MAO generation in vivo.
Journal ArticleDOI
Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.
Yi Han,Qiong Jia,Pedram Shafiei Jahani,Benjamin P. Hurrell,Calvin Pan,Pin Huang,Janet Gukasyan,Nicholas C. Woodward,Eleazar Eskin,Frank D. Gilliland,Omid Akbari,Jaana Hartiala,Hooman Allayee +12 more
TL;DR: A genome-wide analysis for asthma is reported, identifying 66 previously unknown asthma loci and demonstrating that the susceptibility alleles in these regions are associated with risk to a greater extent in men than women, and a murine anti-CD52 antibody mimics the immune cell-depleting effects of a clinically used human anti- CD52 antibody and reduces allergen-induced airway hyperreactivity in mice.
Journal ArticleDOI
A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population.
Rajkumar Dorajoo,Ye Sun,Yi Han,Yi Han,Tingjing Ke,Tingjing Ke,Ayala Burger,Ayala Burger,Ayala Burger,Xuling Chang,Xuling Chang,Hui Qi Low,Weihua Guan,Rozenn N. Lemaitre,Chiea Chuen Khor,Jian-Min Yuan,Woon-Puay Koh,Choon Nam Ong,E. Shyong Tai,Jianjun Liu,Jianjun Liu,Rob M. van Dam,Chew-Kiat Heng,Chew-Kiat Heng,Yechiel Friedlander +24 more
TL;DR: It is shown that genetic loci that influence plasma concentrations of n-3 and n-6 PUFAs are shared across different ethnic groups.
Journal ArticleDOI
Genome-wide analysis identifies novel susceptibility loci for myocardial infarction
Jaana Hartiala,Yi Han,Qiong Jia,James R. Hilser,Pin Huang,Janet Gukasyan,William S Schwartzman,Zhiheng Cai,Subarna Biswas,David-Alexandre Trégouët,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Marcus M. Seldin,Calvin Pan,Margarete Mehrabian,Aldons J. Lusis,Peter Bazeley,Yan V. Sun,Chang Liu,Arshed A. Quyyumi,Markus Scholz,Joachim Thiery,Graciela E. Delgado,Marcus E. Kleber,Winfried März,Winfried März,Winfried März,Laurence J. Howe,Folkert W. Asselbergs,Folkert W. Asselbergs,Marion van Vugt,Georgios J. Vlachojannis,Riyaz S. Patel,Riyaz S. Patel,Leo-Pekka Lyytikäinen,Mika Kähönen,Terho Lehtimäki,Tuomo Nieminen,Pekka Kuukasjärvi,Jari Laurikka,Xuling Chang,Xuling Chang,Chew-Kiat Heng,Chew-Kiat Heng,Rong Jiang,William E. Kraus,Elizabeth R. Hauser,Jane F. Ferguson,Muredach P. Reilly,Kaoru Ito,Satoshi Koyama,Yoichiro Kamatani,Yoichiro Kamatani,Issei Komuro,Lindsey K. Stolze,Casey E. Romanoski,Mohammad Daud Khan,Adam W. Turner,Clint L. Miller,Redouane Aherrahrou,Mete Civelek,Lijiang Ma,Johan L.M. Björkegren,Johan L.M. Björkegren,S. Ram Kumar,W.H. Wilson Tang,Stanley L. Hazen,Hooman Allayee +68 more
TL;DR: A large-scale analysis comprising ∼831 000 subjects revealed novel genetic determinants of MI and implicated SLC44A3 in the pathophysiology of vulnerable plaques and thrombus formation as mentioned in this paper.
Journal ArticleDOI
Fibre-based scaffolding techniques for tendon tissue engineering.
TL;DR: The techniques that have been used to assemble fibres into scaffolds for tendon TE application were reviewed and the morphological structures, mechanical properties, materials, degradation characteristics, and biological activities of the induced scaffolds were compared.